MR relaxometry of the liver

• Verfasst von: Heye, Tobias [VerfasserIn]
• Verfasst von: Yang, Schu-Ren [VerfasserIn]
• Verfasst von: Bock, Michael [VerfasserIn]
• Verfasst von: Brost, Sylvia [VerfasserIn]
• Verfasst von: Weigand, Kilian [VerfasserIn]
• Verfasst von: Longerich, Thomas [VerfasserIn]
• Verfasst von: Kauczor, Hans-Ulrich [VerfasserIn]
• Verfasst von: Hosch, Waldemar P. [VerfasserIn]
• Titel: MR relaxometry of the liver
• Titelzusatz: significant elevation of T1 relaxation time in patients with liver cirrhosis
• Verf.angabe: Tobias Heye, Schu-Ren Yang, Michael Bock, Sylvia Brost, Kilian Weigand, Thomas Longerich, Hans-Ulrich Kauczor, Waldemar Hosch
• Umfang: 9 S.
• Fussnoten: First online: 03 February 2012 ; Gesehen am 15.06.2018
• Titel Quelle: Enthalten in: European radiology
• Jahr Quelle: 2012
• Band/Heft Quelle: 22(2012), 6, S. 1224-1232
• ISSN Quelle: 1432-1084
• ISSN Quelle: 1613-3757
• DOI: doi:10.1007/s00330-012-2378-5
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1576393879

Abstract

Objectives: To evaluate hepatic relaxation times T1, T2 and T2* in healthy subjects and patients with liver cirrhosis stratified by the Child-Pugh classification (CPC). Methods: Sixty-one consecutive patients were stratified by CPC (class A = 26; B = 20; C = 15) and compared with age-matched controls (n = 31). Relaxometry measurements were performed at 1.5 T using six saturation recovery times (200-3,000 ms) to determine liver T1, six echo times (TE 14-113 ms) for T2 and eight TE (4.8-38 ms) for T2* assessment. Signal intensities in selected regions of interest in the liver parenchyma were fitted to theoretical models with least squares minimisation algorithms to determine T1, T2 and T2*. Results: The most significant difference was the higher T1 values (852 ± 132 ms) in cirrhotic livers compared with controls (678 ± 45 ms, P < 0.0001). A less significant difference was seen for T2* (23 ± 5 vs. 26 ± 7 ms). Subdifferentiation showed a statistically significant difference between control group and individual CPC classes as well as between class C and classes A or B for T1 relaxation times. Conclusion: Measurement of T1 relaxation time can differentiate healthy subjects from patients with liver cirrhosis, and can distinguish between mild/moderate disease (CPC A/B) and advanced disease (CPC C). Key Points: Significantly elevated magnetic resonance T1 relaxation times are found in liver cirrhosis. T1 relaxation times can distinguish healthy subjects from patients with liver cirrhosis. T1 relaxation times can distinguish Child-Pugh classes A and B from C.