Clinical relevance of HLA antibodies in kidney transplantation

• Verfasst von: Süsal, Caner [VerfasserIn]
• Verfasst von: Fichtner, Alexander [VerfasserIn]
• Verfasst von: Tönshoff, Burkhard [VerfasserIn]
• Verfasst von: Mehrabi, Arianeb [VerfasserIn]
• Verfasst von: Zeier, Martin [VerfasserIn]
• Verfasst von: Morath, Christian [VerfasserIn]
• Titel: Clinical relevance of HLA antibodies in kidney transplantation
• Titelzusatz: recent data from the Heidelberg Transplant Center and the Collaborative Transplant Study
• Verf.angabe: Caner Süsal, Alexander Fichtner, Burkhard Tönshoff, Arianeb Mehrabi, Martin Zeier, and Christian Morath
• Jahr: 2017
• Umfang: 8 S.
• Fussnoten: Published 4 June 2017 ; Gesehen am 15.06.2018
• Titel Quelle: Enthalten in: Journal of Immunology Research
• Ort Quelle: New York, NY : Hindawi, 2014
• Jahr Quelle: 2017
• Band/Heft Quelle: (2017) Artikel-Nummer ID 5619402, 8 Seiten
• ISSN Quelle: 2314-7156
• DOI: doi:10.1155/2017/5619402
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1576398870

Abstract

Herein, we summarize our recent findings from the international Collaborative Transplant Study (CTS) and Heidelberg Transplant Center regarding the role of HLA antibodies in kidney transplantation and their application into the clinical routine. Based on the antibody findings from the CTS serum study, an algorithm was developed in 2006 for the transplantation of high-risk sensitized patients at the Heidelberg Transplant Center which includes seven different pre- and posttransplant measures. Using this algorithm, the number of transplantations could be increased in high-risk presensitized patients and the previously existing impact of antibodies on graft survival could greatly be diminished but not totally eliminated. More recent findings led to the hypothesis that T cell help from a preactivated immune system supports the harmful effects of pretransplant donor-specific HLA antibodies that otherwise disappear in many cases after transplantation without any consequence.