| Online-Ressource |
Verfasst von: | Polo, Sophie E. [VerfasserIn]  |
| Kzhyshkowska, Julia [VerfasserIn]  |
Titel: | Regulation of DNA-End resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair |
Verf.angabe: | Sophie E. Polo, Andrew N. Blackford, J. Ross Chapman, Linda Baskcomb, Serge Gravel, Andre Rusch, Anoushka Thomas, Rachel Blundred, Philippa Smith, Julia Kzhyshkowska, Thomas Dobner, A. Malcolm R. Taylor, Andrew S. Turnell, Grant S. Stewart, Roger J. Grand and Stephen P. Jackson |
Jahr: | 2012 |
Umfang: | 12 S. |
Fussnoten: | Available online 23 February ; Gesehen am 15.06.2018 |
Titel Quelle: | Enthalten in: Molecular cell |
Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1997 |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 45(2012), 4, Seite 505-516 |
ISSN Quelle: | 1097-4164 |
Abstract: | Summary: DNA double-strand break (DSB) signaling and repair are critical for cell viability, and rely on highly coordinated pathways whose molecular organization is still incompletely understood. Here, we show that heterogeneous nuclear ribonucleoprotein U-like (hnRNPUL) proteins 1 and 2 play key roles in cellular responses to DSBs. We identify human hnRNPUL1 and -2 as binding partners for the DSB sensor complex MRE11-RAD50-NBS1 (MRN) and demonstrate that hnRNPUL1 and -2 are recruited to DNA damage in an interdependent manner that requires MRN. Moreover, we show that hnRNPUL1 and -2 stimulate DNA-end resection and promote ATR-dependent signaling and DSB repair by homologous recombination, thereby contributing to cell survival upon exposure to DSB-inducing agents. Finally, we establish that hnRNPUL1 and -2 function downstream of MRN and CtBP-interacting protein (CtIP) to promote recruitment of the BLM helicase to DNA breaks. Collectively, these results provide insights into how mammalian cells respond to DSBs. |
DOI: | doi:10.1016/j.molcel.2011.12.035 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: http://dx.doi.org/10.1016/j.molcel.2011.12.035 |
| kostenfrei: Volltext: http://www.sciencedirect.com/science/article/pii/S1097276512000457 |
| DOI: https://doi.org/10.1016/j.molcel.2011.12.035 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1576399761 |
Verknüpfungen: | → Zeitschrift |
Regulation of DNA-End resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair / Polo, Sophie E. [VerfasserIn]; 2012 (Online-Ressource)