Status: Bibliographieeintrag
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| |  Online-Ressource |
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| Verfasst von: | Hidmark, Asa S. [VerfasserIn]  |
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| | Nawroth, Peter Paul [VerfasserIn] |
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| | Fleming, Thomas [VerfasserIn] |
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| Titel: | STZ causes depletion of immune cells in sciatic nerve and dorsal root ganglion in experimental diabetes |
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| Verf.angabe: | Asa S. Hidmark, Peter P. Nawroth, Thomas Fleming |
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| Umfang: | 7 S. |
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| Fussnoten: | Available online 11 March 2017 ; Gesehen am 15.06.2018 |
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| Titel Quelle: | Enthalten in: Journal of neuroimmunology |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 306(2017), S. 76-82 |
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| ISSN Quelle: | 1872-8421 |
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| Abstract: | Streptozotocin (STZ) treatment, a common model for inducing diabetes in rodent models, induces thermal hyperalgesia and neuronal toxicity independently of hyperglycemia by oxidizing and activating TRPA1 and TRPV1. Following treatment with STZ, CD45+ immune cells were found to be depleted in sciatic nerve (SN) and DRG in mice, prior to hyperglycemia. Macrophages were also lost in DRG and NFκB-p65-activation was increased in SN macrophages. Immune cells were significantly reduced in both SN and DRG up to three weeks, post-treatment. Loss of PNS-resident macrophages in response to STZ-mediated toxicity may affect the regenerative capacity of the nerve in response to further injury caused by diabetes. |
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| DOI: | doi:10.1016/j.jneuroim.2017.03.008 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Verlag: http://dx.doi.org/10.1016/j.jneuroim.2017.03.008 |
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| | Verlag: http://www.sciencedirect.com/science/article/pii/S016557281630248X |
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| | DOI: https://doi.org/10.1016/j.jneuroim.2017.03.008 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1576410110 |
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| Verknüpfungen: | → Zeitschrift |
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STZ causes depletion of immune cells in sciatic nerve and dorsal root ganglion in experimental diabetes / Hidmark, Asa S. [VerfasserIn] (Online-Ressource)
68261856
