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Status: Bibliographieeintrag

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Verfasst von:Ganzinger, Matthias [VerfasserIn]   i
 He, Shan [VerfasserIn]   i
 Breuhahn, Kai [VerfasserIn]   i
 Knaup-Gregori, Petra [VerfasserIn]   i
Titel:On the ontology based representation of cell lines
Verf.angabe:Matthias Ganzinger, Shan He, Kai Breuhahn, Petra Knaup
E-Jahr:2012
Jahr:November 7, 2012
Umfang:12 S.
Fussnoten:Gesehen am 15.06.2018
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2012
Band/Heft Quelle:7(2012,11) Artikel-Nummer e48584, 12 Seiten
ISSN Quelle:1932-6203
Abstract:Cell lines are frequently used as highly standardized and reproducible in vitro models for biomedical analyses and assays. Cell lines are distributed by cell banks that operate databases describing their products. However, the description of the cell lines' properties are not standardized across different cell banks. Existing cell line-related ontologies mostly focus on the description of the cell lines' names, but do not cover aspects like the origin or optimal growth conditions. The objective of this work is to develop an ontology that allows for a more comprehensive description of cell lines and their metadata, which should cover the data elements provided by cell banks. This will provide the basis for the standardized annotation of cell lines and corresponding assays in biomedical research. In addition, the ontology will be the foundation for automated evaluation of such assays and their respective protocols in the future. To accomplish this, a broad range of cell bank databases as well as existing ontologies were analyzed in a comprehensive manner. We identified existing ontologies capable of covering different aspects of the cell line domain. However, not all data fields derived from the cell banks' databases could be mapped to existing ontologies. As a result, we created a new ontology called cell culture ontology (CCONT) integrating existing ontologies where possible. CCONT provides classes from the areas of cell line identification, origin, cell line properties, propagation and tests performed.
DOI:doi:10.1371/journal.pone.0048584
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: http://dx.doi.org/10.1371/journal.pone.0048584
 kostenfrei: Volltext: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048584
 DOI: https://doi.org/10.1371/journal.pone.0048584
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cell cultures
 Chemical compounds
 Cytogenetics
 Ethnic epidemiology
 Hepatocellular carcinoma
 Internet
 Network analysis
 Ontologies
K10plus-PPN:1576421732
Verknüpfungen:→ Zeitschrift

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