Multiple essential roles for primary cilia in heart development

• Verfasst von: Willaredt, Marc August [VerfasserIn]
• Verfasst von: Gorgas, Karin [VerfasserIn]
• Verfasst von: Tucker, Kerry [VerfasserIn]
• Titel: Multiple essential roles for primary cilia in heart development
• Verf.angabe: Marc August Willaredt, Karin Gorgas, Humphrey A.R. Gardner, Kerry L. Tucker
• Jahr: 2012
• Umfang: 1 S.
• Fussnoten: Published: 11 December 2012 ; Gesehen am 18.06.2018
• Titel Quelle: Enthalten in: Cilia
• Ort Quelle: London : Biomed Central, 2012
• Jahr Quelle: 2012
• Band/Heft Quelle: 1(2012), Seite 23
• ISSN Quelle: 2046-2530
• DOI: doi:10.1186/2046-2530-1-23
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Alpha-actinin
• Sach-SW: Aorta
• Sach-SW: AVSD
• Sach-SW: Bmp2
• Sach-SW: Bmp4
• Sach-SW: Cardiac neural crest
• Sach-SW: Endocardial cushions
• Sach-SW: Hand1
• Sach-SW: Heart
• Sach-SW: Isl1
• Sach-SW: Nkx2.5
• Sach-SW: Outflow tract
• Sach-SW: Pitx2c
• Sach-SW: Primary cilia
• Sach-SW: Pulmonary trunk
• Sach-SW: Shh
• K10plus-PPN: 1576485471

Abstract

The primary cilium is a microtubule-based, plasma membrane-ensheathed protrusion projecting from the basal bodies of almost all cell types in the mammalian body. In the past several years a plethora of papers has indicated a crucial role for primary cilia in the development of a wide variety of organs. We have investigated heart development in cobblestone, a hypomorphic allele of the gene encoding the intraflagellar transport protein Ift88, and uncovered a number of the most common congenital heart defects seen in newborn humans.