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Verfasst von:Biedermann, Sarah Violetta [VerfasserIn]   i
 Zheng, Lei [VerfasserIn]   i
 Vollmayr, Barbara [VerfasserIn]   i
 Gass, Peter [VerfasserIn]   i
 Ende, Gabriele [VerfasserIn]   i
 Sartorius, Alexander [VerfasserIn]   i
Titel:Increase of hippocampal glutamate after electroconvulsive treatment
Titelzusatz:a quantitative proton MR spectroscopy study at 9.4 T in an animal model of depression
Verf.angabe:Sarah Biedermann, Wolfgang Weber-Fahr, Lei Zheng, Carolin Hoyer, Barbara Vollmayr, Peter Gass, Gabriele Ende and Alexander Sartorius
Jahr:2012
Jahr des Originals:2011
Umfang:11 S.
Fussnoten:Gesehen am 18.06.2018 ; Published online: 18 Jul 2011
Titel Quelle:Enthalten in: The world journal of biological psychiatry
Ort Quelle:Abingdon : Taylor & Francis Group, 2000
Jahr Quelle:2012
Band/Heft Quelle:13(2012), 6, Seite 447-457
ISSN Quelle:1814-1412
Abstract:Objectives. Recent evidence suggests that alterations in hippocampal glutamate and gamma-aminobutyric acid (GABA) are associated with the pathomechanism of depression and treatment effects of electroconvulsive therapy (ECT). Thus, proton magnetic resonance spectroscopy (H-1 MRS) at a 9.4 T animal system seems a promising tool to study underlying mechanisms since it allows for an accurate quantification of metabolites with distinction of glutamate, GABA and glutamine, as well as separation of taurine from choline. Methods. A well-validated animal model of treatment resistant depression (congenital learned helpless rats = cLH) was investigated by hippocampal in vivo H-1 MRS with and without a 1-week course of electroconvulsive shocks (ECS), an animal model of ECT, and compared to wild type (WT) animals, while saline and clomipramine injections served as additional controls. Results. Untreated cLH rats showed significantly lower glucose and higher taurine concentrations compared to WT animals. Besides alterations on these metabolites, ECS increased glutamate in WT and cLH and choline in cLH rats. Moreover, correlations between glutamate and GABA concentrations with learned helpless behaviour were revealed. Conclusions. These findings support the idea of disordered hippocampal metabolism in an animal model of treatment resistant depression and suggest an early impact of ECS on MR-detectable hippocampal metabolites.
DOI:doi:10.3109/15622975.2011.580778
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.3109/15622975.2011.580778
 Volltext: http://dx.doi.org/10.3109/15622975.2011.580778
 DOI: https://doi.org/10.3109/15622975.2011.580778
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Brain imaging
 danish pet/depression project
 electroconvulsive therapy
 frontal-cortex
 gaba concentrations
 gamma-aminobutyric-acid
 in-vivo
 learned helplessness
 magnetic resonance spectroscopy
 magnetic-resonance-spectroscopy
 major depression
 major depressive disorder
 mood disorders
 rat-brain
K10plus-PPN:1576487571
Verknüpfungen:→ Zeitschrift

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