Post-translational modifications of centromeric chromatin

• Verfasst von: García del Arco, Ana [VerfasserIn]
• Verfasst von: Erhardt, Sylvia [VerfasserIn]
• Titel: Post-translational modifications of centromeric chromatin
• Verf.angabe: Ana García del Arco, Sylvia Erhardt
• Jahr: 2017
• Umfang: 19 S.
• Fussnoten: First online: 25 August 2017 ; Gesehen am 19.06.2018
• Titel Quelle: Enthalten in: Centromeres and Kinetochores
• Ort Quelle: Cham : Springer, 2017
• Jahr Quelle: 2017
• Band/Heft Quelle: (2017), Seite 213-231
• ISBN Quelle: 978-3-319-58592-5
• DOI: doi:10.1007/978-3-319-58592-5_9
• Datenträger: Online-Ressource
• Sprache: eng
• Bibliogr. Hinweis: Erscheint auch als : Druck-Ausgabe: García del Arco, Ana: Post-translational modifications of centromeric chromatin. - 2017
• K10plus-PPN: 1576511154

Abstract

Regulation of chromatin structures is important for the control of DNA processes such as gene expression, and misregulation of chromatin is implicated in diverse diseases. Covalent post-translational modifications of histones are a prominent way to regulate chromatin structure and different chromatin regions bear their specific signature of histone modifications. The composition of centromeric chromatin is significantly different from other chromatin structures and mainly defined by the presence of the histone H3-variant CENP-A. Here we summarize the composition of centromeric chromatin and what we know about its differential regulation by post-translational modifications.