| |  Online-Ressource |
|---|
| Verfasst von: | Graf, Mirja E. [VerfasserIn]  |
|---|
| | Sookthai, Disorn [VerfasserIn] |
|---|
| | Johnson, Theron S. [VerfasserIn] |
|---|
| | Schübel, Ruth [VerfasserIn] |
|---|
| | Katzke, Verena [VerfasserIn] |
|---|
| | Bugert, Peter [VerfasserIn] |
|---|
| | Hoffmeister, Michael [VerfasserIn] |
|---|
| | Kaaks, Rudolf [VerfasserIn] |
|---|
| | Kühn, Tilman [VerfasserIn] |
|---|
| Titel: | Biological reproducibility of circulating P-Selectin, Thrombopoietin, GPIIb/IIIa and Thrombomodulin over one year |
|---|
| Verf.angabe: | Mirja E. Graf, Disorn Sookthai, Theron Johnson, Ruth Schübel, Verena Katzke, Peter Bugert, Michael Hoffmeister, Rudolf Kaaks, Tilman Kühn |
|---|
| Jahr: | 2017 |
|---|
| Umfang: | 5 S. |
|---|
| Fussnoten: | Gesehen am 19.06.2018 ; Available online 29 May 2017 |
|---|
| Titel Quelle: | Enthalten in: Clinical biochemistry |
|---|
| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1967 |
|---|
| Jahr Quelle: | 2017 |
|---|
| Band/Heft Quelle: | 50(2017), 16, Seite 942-946 |
|---|
| ISSN Quelle: | 1873-2933 |
|---|
| Abstract: | Background: Enhanced platelet activation has been implicated in several pathophysiological processes. Here, we evaluated the biological reproducibility of circulating P-Selectin, Thrombomodulin (TM), Thrombopoietin (TPO), and Glycoprotein IIb/IIIa (GPIIb/IIIa) to assess whether these analytes can be used as reliable biomarkers of platelet activation in epidemiological studies. Methods: We measured circulating P-Selectin, TM, TPO and GPIIb/IIIa by immunoassays in two blood samples of 78 participants of the EPIC Heidelberg study (47-80years, 50% female) that were collected one year apart. Biological reproducibility of biomarker levels over time and associations with routine biochemistry parameters were assessed by Spearman's correlation coefficients. Results: Statistical analyses revealed good reproducibility over one year for two of the analyzed markers, with Spearman coefficients of ρ=0.80 (P-Selectin) and ρ=0.73 (TPO) and reasonable reproducibility for TM (ρ=0.63) and GPIIb/IIIa (ρ=0.51). Levels of P-Selectin, TM, TPO and GPIIb/IIIa were not significantly associated with routine biochemistry parameters, such as glucose, HbA1c, LDL, HDL, Triglycerides and CRP. Conclusions: Our findings suggest that a single assessment of P-Selectin, TM, TPO and GPIIb/IIIa at baseline in prospective epidemiological studies is appropriate to investigate associations between platelet activation and risks of chronic diseases. |
|---|
| DOI: | doi:10.1016/j.clinbiochem.2017.05.017 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.clinbiochem.2017.05.017 |
|---|
| | Volltext: http://www.sciencedirect.com/science/article/pii/S0009912017302515 |
|---|
| | DOI: https://doi.org/10.1016/j.clinbiochem.2017.05.017 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Biological reproducibility |
|---|
| | Glycoprotein IIb/IIIa |
|---|
| | Intra-individual variation |
|---|
| | P-Selectin |
|---|
| | Thrombomodulin |
|---|
| | Thrombopoietin |
|---|
| K10plus-PPN: | 1576537668 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Biological reproducibility of circulating P-Selectin, Thrombopoietin, GPIIb/IIIa and Thrombomodulin over one year / Graf, Mirja E. [VerfasserIn]; 2017 (Online-Ressource)
