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Status: Bibliographieeintrag

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Verfasst von:Graf, Mirja E. [VerfasserIn]   i
 Sookthai, Disorn [VerfasserIn]   i
 Johnson, Theron S. [VerfasserIn]   i
 Schübel, Ruth [VerfasserIn]   i
 Katzke, Verena [VerfasserIn]   i
 Bugert, Peter [VerfasserIn]   i
 Hoffmeister, Michael [VerfasserIn]   i
 Kaaks, Rudolf [VerfasserIn]   i
 Kühn, Tilman [VerfasserIn]   i
Titel:Biological reproducibility of circulating P-Selectin, Thrombopoietin, GPIIb/IIIa and Thrombomodulin over one year
Verf.angabe:Mirja E. Graf, Disorn Sookthai, Theron Johnson, Ruth Schübel, Verena Katzke, Peter Bugert, Michael Hoffmeister, Rudolf Kaaks, Tilman Kühn
Jahr:2017
Umfang:5 S.
Fussnoten:Gesehen am 19.06.2018 ; Available online 29 May 2017
Titel Quelle:Enthalten in: Clinical biochemistry
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1967
Jahr Quelle:2017
Band/Heft Quelle:50(2017), 16, Seite 942-946
ISSN Quelle:1873-2933
Abstract:Background: Enhanced platelet activation has been implicated in several pathophysiological processes. Here, we evaluated the biological reproducibility of circulating P-Selectin, Thrombomodulin (TM), Thrombopoietin (TPO), and Glycoprotein IIb/IIIa (GPIIb/IIIa) to assess whether these analytes can be used as reliable biomarkers of platelet activation in epidemiological studies. Methods: We measured circulating P-Selectin, TM, TPO and GPIIb/IIIa by immunoassays in two blood samples of 78 participants of the EPIC Heidelberg study (47-80years, 50% female) that were collected one year apart. Biological reproducibility of biomarker levels over time and associations with routine biochemistry parameters were assessed by Spearman's correlation coefficients. Results: Statistical analyses revealed good reproducibility over one year for two of the analyzed markers, with Spearman coefficients of ρ=0.80 (P-Selectin) and ρ=0.73 (TPO) and reasonable reproducibility for TM (ρ=0.63) and GPIIb/IIIa (ρ=0.51). Levels of P-Selectin, TM, TPO and GPIIb/IIIa were not significantly associated with routine biochemistry parameters, such as glucose, HbA1c, LDL, HDL, Triglycerides and CRP. Conclusions: Our findings suggest that a single assessment of P-Selectin, TM, TPO and GPIIb/IIIa at baseline in prospective epidemiological studies is appropriate to investigate associations between platelet activation and risks of chronic diseases.
DOI:doi:10.1016/j.clinbiochem.2017.05.017
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.clinbiochem.2017.05.017
 Volltext: http://www.sciencedirect.com/science/article/pii/S0009912017302515
 DOI: https://doi.org/10.1016/j.clinbiochem.2017.05.017
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Biological reproducibility
 Glycoprotein IIb/IIIa
 Intra-individual variation
 P-Selectin
 Thrombomodulin
 Thrombopoietin
K10plus-PPN:1576537668
Verknüpfungen:→ Zeitschrift

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