Mastectomy trends for early-stage breast cancer

• Verfasst von: Garcia-Etienne, Carlos A. [VerfasserIn]
• Verfasst von: Heil, Jörg [VerfasserIn]
• Titel: Mastectomy trends for early-stage breast cancer
• Titelzusatz: a report from the EUSOMA multi-institutional European database
• Verf.angabe: Carlos A. Garcia-Etienne, Mariano Tomatis, Joerg Heil, Kay Friedrichs, Rolf Kreienberg, Andreas Denk, Marion Kiechle, Fatemeh Lorenz-Salehi, Rainer Kimmig, Günter Emons, Mahmoud Danaei, Volker Heyl, Uwe Heindrichs, Christoph J. Rageth, Wolfgang Janni, Lorenza Marotti, Marco Rosselli del Turco, Antonio Ponti, eusomaDB Working Group
• Jahr: 2012
• Umfang: 10 S.
• Illustrationen: Illustrationen
• Fussnoten: Available online 4 April 2012 ; Gesehen am 20.06.2018
• Titel Quelle: Enthalten in: European journal of cancer
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 1965
• Jahr Quelle: 2012
• Band/Heft Quelle: 48(2012), 13, Seite 1947-1956
• ISSN Quelle: 1879-0852
• DOI: doi:10.1016/j.ejca.2012.03.008
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Breast surgery
• Sach-SW: Breast surgery in Europe
• Sach-SW: Mastectomies
• Sach-SW: Mastectomy
• Sach-SW: Mastectomy rates
• Sach-SW: Mastectomy trends
• Sach-SW: Rates in Europe
• Sach-SW: Surgery for breast cancer
• Sach-SW: Surgery trends in Europe
• Sach-SW: Trends in Europe
• K10plus-PPN: 1576551199

Abstract

Introduction: Recent single-institution reports have shown increased mastectomy rates during the last decade. Further studies aiming to determine if these reports could be reflecting a national trend in the United States of America (US) have shown conflicting results. We report these trends from a multi-institutional European database. Patients and methods. Our source of data was the eusomaDB, a central data warehouse of prospectively collected information of the European Society of Breast Cancer Specialists (EUSOMA). We identified patients with newly diagnosed unilateral early-stage breast cancer (stages 0, I or II) to examine rates and trends in surgical treatment. Results: A total of 15,369 early-stage breast cancer cases underwent surgery in 13 Breast Units from 2003 to 2010. Breast conservation was successful in 11,263 cases (73.3%). Adjusted trend by year showed a statistically significant decrease in mastectomy rates from 2005 to 2010 (p=0.003) with a progressive reduction of 4.24% per year. A multivariate model showed a statistically significant association of the following factors with mastectomy: age <40 or ⩾70years, pTis, pT1mi, positive axillary nodes, lobular histology, tumour grade II and III, negative progesterone receptors and multiple lesions. Conclusion: Our study demonstrates that a high proportion of patients with newly diagnosed unilateral early-stage breast cancer from the eusomaDB underwent breast-conserving surgery. It also shows a significant trend of decreasing mastectomy rates from 2005 to 2010. Moreover, our study suggests mastectomy rates in the population from the eusomaDB are lower than those reported in the US.