A frequent misinterpretation in current research on liver fibrosis

• Verfasst von: Hammad, Seddik [VerfasserIn]
• Verfasst von: Meyer, Christoph [VerfasserIn]
• Verfasst von: Mohamed, Fatma El Zahraa [VerfasserIn]
• Verfasst von: Dooley, Steven [VerfasserIn]
• Titel: A frequent misinterpretation in current research on liver fibrosis
• Titelzusatz: the vessel in the center of CCl4-induced pseudolobules is a portal vein
• Verf.angabe: Seddik Hammad, Albert Braeuning, Christoph Meyer, Fatma El Zahraa Ammar Mohamed, Jan G. Hengstler, Steven Dooley
• Jahr: 2017
• Umfang: 4 S.
• Fussnoten: First online: 19 August 2017 ; Gesehen am 21.06.2018 ; Im Zusatztitel ist die Zahl 4 tiefgestellt
• Titel Quelle: Enthalten in: Archives of toxicology
• Ort Quelle: Berlin : Springer, 1930
• Jahr Quelle: 2017
• Band/Heft Quelle: 91(2017), 11, Seite 3689-3692
• ISSN Quelle: 1432-0738
• DOI: doi:10.1007/s00204-017-2040-8
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1576718751

Abstract

Carbon tetrachloride-induced liver injury is a thoroughly studied model for regeneration and fibrosis in rodents. Nevertheless, its pattern of liver fibrosis is frequently misinterpreted as portal type. To clarify this, we show that collagen type IV+ “streets” and α-SMA+ cells accumulate pericentrally and extend to neighbouring central areas of the liver lobule, forming a ‘pseudolobule’. Blood vessels in the center of such pseudolobules are portal veins as indicated by the presence of bile duct cells (CK19+) and the absence of pericentral hepatocytes (glutamine synthetase+). It is critical to correctly describe this pattern of fibrosis, particulary for metabolic zonation studies.