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Verfasst von:Himbert, Caroline [VerfasserIn]   i
 Delphan, Mahmoud [VerfasserIn]   i
 Scherer, Dominique [VerfasserIn]   i
 Bowers, Laura W. [VerfasserIn]   i
 Hursting, Stephen [VerfasserIn]   i
 Ulrich, Cornelia [VerfasserIn]   i
Titel:Signals from the adipose microenvironment and the obesity -cancer link - a systematic review
Verf.angabe:Caroline Himbert, Mahmoud Delphan, Dominique Scherer, Laura W. Bowers, Stephen Hursting, and Cornelia M. Ulrich
Jahr:2017
Umfang:13 S.
Fussnoten:Published Online First September 1, 2017 ; Gesehen am 22.06.2018
Titel Quelle:Enthalten in: Cancer Prevention Research
Ort Quelle:Philadelphia, Pa. : AACR, 2008
Jahr Quelle:2017
Band/Heft Quelle:10(2017), 9, Seite 494-506
ISSN Quelle:1940-6215
Abstract:Obesity and its associated metabolic dysregulation are established risk factors for many cancers. However, the biologic mechanisms underlying this relationship remain incompletely understood. Given the rising rates of both obesity and cancer worldwide, and the challenges for many people to lose excess adipose tissue, a systematic approach to identify potential molecular and metabolic targets is needed to develop effective mechanism-based strategies for the prevention and control of obesity-driven cancer. Epidemiologic, clinical, and preclinical data suggest that within the growth-promoting, proinflammatory microenvironment accompanying obesity, crosstalk between adipose tissue (comprised of adipocytes, macrophages and other cells) and cancer-prone cells may occur via obesity-associated hormones, cytokines, and other mediators that have been linked to increased cancer risk and/or progression. We report here a systematic review on the direct “crosstalk” between adipose tissue and carcinomas in humans. We identified 4,641 articles with n = 20 human clinical studies, which are summarized as: (i) breast (n = 7); (ii) colorectal (n = 4); (iii) esophageal (n = 2); (iv) esophageal/colorectal (n = 1); (v) endometrial (n = 1); (vi) prostate (n = 4); and (vii) ear-nose-throat (ENT) cancer (n = 1). Findings from these clinical studies reinforce preclinical data and suggest organ-dependent crosstalk between adipose tissue and carcinomas via VEGF, IL6, TNFα, and other mechanisms. Moreover, visceral white adipose tissue plays a more central role, as it is more bioenergetically active and is associated with a more procancer secretome than subcutaneous adipose tissue. Efforts to eavesdrop and ultimately interfere with this cancer-enhancing crosstalk may lead to new targets and strategies for decreasing the burden of obesity-related cancers.
DOI:doi:10.1158/1940-6207.CAPR-16-0322
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1158/1940-6207.CAPR-16-0322
 Volltext: http://cancerpreventionresearch.aacrjournals.org/content/10/9/494
 DOI: https://doi.org/10.1158/1940-6207.CAPR-16-0322
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1576761010
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