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Verfasst von:Buldakov, Mikhail [VerfasserIn]   i
 Riabov, Vladimir [VerfasserIn]   i
 Yin, Shuiping [VerfasserIn]   i
 Kzhyshkowska, Julia [VerfasserIn]   i
Titel:CD68+, but not stabilin-1+ tumor associated macrophages in gaps of ductal tumor structures negatively correlate with the lymphatic metastasis in human breast cancer
Verf.angabe:Mikhail Buldakov, Marina Zavyalova, Nadezhda Krakhmal, Nadezhda Telegina, Sergei Vtorushin, Irina Mitrofanova, Vladimir Riabov, Shuiping Yin, Bin Song, Nadezhda Cherdyntseva, Julia Kzhyshkowska
Jahr:2017
Jahr des Originals:2015
Umfang:8 S.
Fussnoten:Gesehen am 22.06.2018 ; Available online 8 September 2015
Titel Quelle:Enthalten in: Immunobiology
Ort Quelle:München : Elsevier, 1979
Jahr Quelle:2017
Band/Heft Quelle:222(2017), 1, Seite 31-38
ISSN Quelle:1878-3279
Abstract:Tumor associated macrophages (TAM) support tumor growth and metastasis in several animal models of breast cancer, and TAM amount is predictive for efficient tumor growth and metastatic spread via blood circulation. However, limited information is available about intratumoral TAM heterogeneity and functional role of TAM subpopulations in tumor progression. The aim of our study was to examine correlation of TAM presence in various morphological segments of human breast cancer with clinical parameters. Thirty six female patients with nonspecific invasive breast cancer T1-4N0-3M0 were included in the study. Morphological examination was performed using Carl Zeiss Axio Lab.A1 and MiraxMidiZeiss. Immunohistochemical and immunofluorescence/confocal microcopy analysis was used to detect CD68 and stabilin-1 in 5 different tumor segments: (1) areas with soft fibrous stroma; (2) areas with coarse fibrous stroma; (3) areas of maximum stromal-and-parenchymal relationship; (4) parenchymal elements; (5) gaps of ductal tumor structures. The highest expression of CD68 was in areas with soft fibrous stroma or areas of maximum stromal-and-parenchymal relationship (79%). The lowest expression of CD68 was in areas with coarse fiber stroma (23%). Inverse correlation of tumor size and expression of CD68 in gaps of tubular tumor structures was found (R=−0.67; p=0.02). In case of the lymph node metastases the average score of CD68 expression in ductal gaps tumor structures was lower (1.4±0.5) compared to negative lymph nodes case (3.1±1.0; F=10.9; p=0.007). Confocal microscopy identified 3 phenotypes of TAM: CD68+/stabilin-1−; CD68+/stabilin-1+ (over 50%); and CD68−/stabilin-1+. However, expression of stabilin-1 did not correlate with lymph node metastasis. We concluded, that increased amount of CD68+TAM in gaps of ductal tumor structures is protective against metastatic spread in regional lymph nodes.
DOI:doi:10.1016/j.imbio.2015.09.011
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.imbio.2015.09.011
 Volltext: http://www.sciencedirect.com/science/article/pii/S0171298515300620
 DOI: https://doi.org/10.1016/j.imbio.2015.09.011
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Breast cancer
 CD68
 Intratumoral heterogeneity
 Lymphatic metastasis
 Stabilin-1
 Tumor-associated macrophages
K10plus-PPN:1576764559
Verknüpfungen:→ Zeitschrift

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