Extracellular regulation of BMP signaling

• Verfasst von: Sedlmeier, Georg [VerfasserIn]
• Verfasst von: Sleeman, Jonathan P. [VerfasserIn]
• Titel: Extracellular regulation of BMP signaling
• Titelzusatz: welcome to the matrix
• Verf.angabe: Georg Sedlmeier and Jonathan P. Sleeman
• Jahr: 2017
• Umfang: 9 S.
• Fussnoten: Version of record published: 15 February 2017 ; Gesehen am 25.06.2018
• Titel Quelle: Enthalten in: Biochemical Society (Großbritannien)Biochemical Society transactions
• Ort Quelle: London : Portland Press, 1973
• Jahr Quelle: 2017
• Band/Heft Quelle: 45(2017), 1, Seite 173-181
• ISSN Quelle: 1470-8752
• DOI: doi:10.1042/BST20160263
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1576822311

Abstract

Given its importance in development and homeostasis, bone morphogenetic protein (BMP) signaling is tightly regulated at the extra- and intracellular level. The extracellular matrix (ECM) was initially thought to act as a passive mechanical barrier that sequesters BMPs. However, a new understanding about how the ECM plays an instructive role in regulating BMP signaling is emerging. In this mini-review, we discuss various ways in which the biochemical and physical properties of the ECM regulate BMP signaling.