Vitamin D status and epigenetic-based mortality risk score

• Verfasst von: Gao, Xu [VerfasserIn]
• Verfasst von: Schöttker, Ben [VerfasserIn]
• Verfasst von: Brenner, Hermann [VerfasserIn]
• Titel: Vitamin D status and epigenetic-based mortality risk score
• Titelzusatz: strong independent and joint prediction of all-cause mortality in a population-based cohort study
• Verf.angabe: Xu Gao, Yan Zhang, Ben Schöttker and Hermann Brenner
• Jahr: 2018
• Umfang: 10 S.
• Teil: volume:10
• Teil: year:2018
• Teil: extent:10
• Fussnoten: Published: 20 June 2018 ; Gesehen am 26.06.2018
• Titel Quelle: Enthalten in: Clinical epigenetics
• Ort Quelle: [S.l.] : BioMed Central, 2010
• Jahr Quelle: 2018
• Band/Heft Quelle: 10(2018) Artikel-Nummer 84, 10 Seiten
• ISSN Quelle: 1868-7083
• DOI: doi:10.1186/s13148-018-0515-y
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: All-cause mortality
• Sach-SW: DNA methylation
• Sach-SW: Epigenetic epidemiology
• Sach-SW: Epigenetic mortality risk score
• Sach-SW: Precision medicine
• Sach-SW: Vitamin D
• K10plus-PPN: 1576876632

Abstract

Vitamin D deficiency and insufficiency have been established to be strongly associated with increased overall mortality and deaths from specific aging-related diseases. Recently, an epigenetic “mortality risk score” (MS) based on whole blood DNA methylation at the 10 most prominent mortality-related cytosine-phosphate-guanine (CpG) sites has also been found to be highly related to all-cause mortality. This study aimed to explore whether vitamin D status, defined by serum 25-hydroxyvitamin D [25(OH)D] concentrations, is associated with the MS and to what extent both indicators are individually and jointly capable of predicting all-cause mortality in a general population sample of older adults.