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Verfasst von:Gimpel, Charlotte [VerfasserIn]   i
 Arnold, Raoul [VerfasserIn]   i
Titel:Magnetic resonance tissue phase mapping demonstrates altered left ventricular diastolic function in children with chronic kidney disease
Verf.angabe:Charlotte Gimpel, Bernd A. Jung, Sabine Jung, Johannes Brado, Daniel Schwendinger, Barbara Burkhardt, Martin Pohl, Katja E. Odening, Julia Geiger, Raoul Arnold
Jahr des Originals:2016
Umfang:9 S.
Fussnoten:Published online: 13 December 2016 ; Gesehen am 27.06.2018
Titel Quelle:Enthalten in: Pediatric radiology
Jahr Quelle:2017
Band/Heft Quelle:47(2017), 2, S. 169-177
ISSN Quelle:1432-1998
Abstract:BackgroundEchocardiographic examinations have revealed functional cardiac abnormalities in children with chronic kidney disease.ObjectiveTo assess the feasibility of MRI tissue phase mapping in children and to assess regional left ventricular wall movements in children with chronic kidney disease.Materials and methodsTwenty pediatric patients with chronic kidney disease (before or after renal transplantation) and 12 healthy controls underwent tissue phase mapping (TPM) to quantify regional left ventricular function through myocardial long (Vz) and short-axis (Vr) velocities at all 3 levels of the left ventricle.ResultsPatients and controls (age: 8 years—20 years) were matched for age, height, weight, gender and heart rate. Patients had higher systolic blood pressure. No patient had left ventricular hypertrophy on MRI or diastolic dysfunction on echocardiography. Fifteen patients underwent tissue Doppler echocardiography, with normal z-scores for mitral early diastolic (VE),late diastolic (VA) and peak systolic (VS) velocities. Throughout all left ventricular levels, peak diastolic Vz and Vr (cm/s) were reduced in patients: Vzbase -10.6 ± 1.9 vs. -13.4 ± 2.0 (P < 0.0003), Vzmid -7.8 ± 1.6 vs. -11 ± 1.5 (P < 0.0001), Vzapex -3.8 ± 1.6 vs. -5.3 ± 1.6 (P = 0.01), Vrbase -4.2 ± 0.8 vs. -4.9 ± 0.7 (P = 0.01), Vrmid -4.7 ± 0.7 vs. -5.4 ± 0.7 (P = 0.01), Vrapex -4.7 ± 1.4 vs. -5.6 ± 1.1 (P = 0.05).ConclusionTissue phase mapping is feasible in children and adolescents. Children with chronic kidney disease show significantly reduced peak diastolic long- and short-axis left ventricular wall velocities, reflecting impaired early diastolic filling. Thus, tissue phase mapping detects chronic kidney disease-related functional myocardial changes before overt left ventricular hypertrophy or echocardiographic diastolic dysfunction occurs.
DOI:doi:10.1007/s00247-016-3741-5
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Verlag: http://dx.doi.org/10.1007/s00247-016-3741-5
 Verlag: https://link.springer.com/article/10.1007/s00247-016-3741-5
 DOI: https://doi.org/10.1007/s00247-016-3741-5
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1576890635
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