Quantification of left and right ventricular function and myocardial mass

• Verfasst von: Takx, Richard A. P. [VerfasserIn]
• Verfasst von: Meyer, Mathias [VerfasserIn]
• Verfasst von: Schönberg, Stefan [VerfasserIn]
• Verfasst von: Fink, Christian [VerfasserIn]
• Verfasst von: Henzler, Thomas [VerfasserIn]
• Titel: Quantification of left and right ventricular function and myocardial mass
• Titelzusatz: comparison of low-radiation dose 2nd generation dual-source CT and cardiac MRI
• Verf.angabe: Richard A.P. Takx, Antonio Moscariello, U. Joseph Schoepf, J. Michael Barraza, John W. Nance, Gorka Bastarrika, Marco Das, Mathias Meyer, Joachim E. Wildberger, Stefan O. Schoenberg, Christian Fink, Thomas Henzler
• Jahr des Originals: 2011
• Umfang: 7 S.
• Fussnoten: Available online 9 August 2011 ; Gesehen am 27.06.2018
• Titel Quelle: Enthalten in: European journal of radiology
• Jahr Quelle: 2012
• Band/Heft Quelle: 81(2012), 4, S. e598-e604
• ISSN Quelle: 1872-7727
• DOI: doi:10.1016/j.ejrad.2011.07.001
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1576896641

Abstract

Objective To prospectively evaluate the accuracy of left and right ventricular function and myocardial mass measurements based on a dual-step, low radiation dose protocol with prospectively ECG-triggered 2nd generation dual-source CT (DSCT), using cardiac MRI (cMRI) as the reference standard. Materials and methods Twenty patients underwent 1.5 T cMRI and prospectively ECG-triggered dual-step pulsing cardiac DSCT. This image acquisition mode performs low-radiation (20% tube current) imaging over the majority of the cardiac cycle and applies full radiation only during a single adjustable phase. Full-radiation-phase images were used to assess cardiac morphology, while low-radiation-phase images were used to measure left and right ventricular function and mass. Quantitative CT measurements based on contiguous multiphase short-axis reconstructions from the axial CT data were compared with short-axis SSFP cardiac cine MRI. Contours were manually traced around the ventricular borders for calculation of left and right ventricular end-diastolic volume, end-systolic volume, stroke volume, ejection fraction and myocardial mass for both modalities. Statistical methods included independent t-tests, the Mann-Whitney U test, Pearson correlation statistics, and Bland-Altman analysis. Results All CT measurements of left and right ventricular function and mass correlated well with those from cMRI: for left/right end-diastolic volume r = 0.885/0.801, left/right end-systolic volume r = 0.947/0.879, left/right stroke volume r = 0.620/0.697, left/right ejection fraction r = 0.869/0.751, and left/right myocardial mass r = 0.959/0.702. Mean radiation dose was 6.2 ± 1.8 mSv. Conclusions Prospectively ECG-triggered, dual-step pulsing cardiac DSCT accurately quantifies left and right ventricular function and myocardial mass in comparison with cMRI with substantially lower radiation exposure than reported for traditional retrospective ECG-gating.