| |  Online-Ressource |
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| Verfasst von: | Schneider, Marc [VerfasserIn]  |
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| | Christopoulos, Petros [VerfasserIn] |
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| | Muley, Thomas [VerfasserIn] |
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| | Warth, Arne [VerfasserIn] |
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| | Klingmüller, Ursula [VerfasserIn] |
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| | Thomas, Michael [VerfasserIn] |
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| | Herth, Felix [VerfasserIn] |
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| | Dienemann, Hendrik [VerfasserIn] |
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| | Meister, Michael [VerfasserIn] |
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| Titel: | AURKA, DLGAP5, TPX2, KIF11 and CKAP5 |
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| Titelzusatz: | five specific mitosis-associated genes correlate with poor prognosis for non-small cell lung cancer patients |
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| Verf.angabe: | Marc A. Schneider, Petros Christopoulos, Thomas Muley, Arne Warth, Ursula Klingmueller, Michael Thomas, Felix J.F. Herth, Hendrik Dienemann, Nikola S. Mueller, Fabian Theis and Michael Meister |
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| Jahr: | 2017 |
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| Umfang: | 8 S. |
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| Teil: | volume:50 |
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| | year:2017 |
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| | number:2 |
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| | pages:365-372 |
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| | extent:8 |
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| Fussnoten: | Published online 2017 Jan 2 ; Gesehen am 27.06.2018 |
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| Titel Quelle: | Enthalten in: International journal of oncology |
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| Ort Quelle: | Athens : Spandidos Publ., 2001 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 50(2017), 2, Seite 365-372 |
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| ISSN Quelle: | 1791-2423 |
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| Abstract: | The growth of a tumor depends to a certain extent on an increase in mitotic events. Key steps during mitosis are the regulated assembly of the spindle apparatus and the separation of the sister chromatids. The microtubule-associated protein Aurora kinase A phosphorylates DLGAP5 in order to correctly segregate the chromatids. Its activity and recruitment to the spindle apparatus is regulated by TPX2. KIF11 and CKAP5 control the correct arrangement of the microtubules and prevent their degradation. In the present study, we investigated the role of these five molecules in non-small cell lung cancer (NSCLC). We analyzed the expression of the five genes in a large cohort of NSCLC patients (n=362) by quantitative real-time PCR. Each of the genes was highly overexpressed in the tumor tissues compared to corresponding normal lung tissue. The correlation of the expression of the individual genes depended on the histology. An increased expression of AURKA, DLGAP5, TPX2, KIF11 and CKAP5 was associated with poor overall survival (P=0.001-0.065). AURKA was a significant prognostic marker using multivariate analyses (P=0.006). Immunofluorescence studies demonstrated that the five mitosis-associated proteins co-localized with the spindle apparatus during cell division. Taken together, our data demonstrate that the expression of the mitosis-associated genes AURKA, DLGAP5, TPX2, KIF11 and CKAP5 is associated with the prognosis of NSCLC patients. |
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| DOI: | doi:10.3892/ijo.2017.3834 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: http://dx.doi.org/10.3892/ijo.2017.3834 |
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| | Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238780/ |
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| | DOI: https://doi.org/10.3892/ijo.2017.3834 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1576910741 |
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| Verknüpfungen: | → Zeitschrift |
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AURKA, DLGAP5, TPX2, KIF11 and CKAP5 / Schneider, Marc [VerfasserIn]; 2017 (Online-Ressource)
