Urinary 8-isoprostane levels and occurrence of lung, colorectal, prostate, breast and overall cancer

• Verfasst von: Gao, Xin [VerfasserIn]
• Verfasst von: Brenner, Hermann [VerfasserIn]
• Verfasst von: Cuk, Katarina [VerfasserIn]
• Verfasst von: Anusruti, Ankita [VerfasserIn]
• Verfasst von: Xuan, Yang [VerfasserIn]
• Verfasst von: Schöttker, Ben [VerfasserIn]
• Titel: Urinary 8-isoprostane levels and occurrence of lung, colorectal, prostate, breast and overall cancer
• Titelzusatz: results from a large, population-based cohort study with 14 years of follow-up
• Verf.angabe: Xīn Gào, Hermann Brenner, Bernd Holleczek, Katarina Cuk, Yan Zhang, Ankita Anusruti, Yang Xuan, Yiwei Xu, Ben Schöttker
• Jahr: 2018
• Umfang: 7 S.
• Teil: volume:123
• Teil: year:2018
• Teil: pages:20-26
• Teil: extent:7
• Fussnoten: Available online 17 May 2018 ; Gesehen am 27.06.2018
• Titel Quelle: Enthalten in: Free radical biology and medicine
• Ort Quelle: New York, NY [u.a.] : Elsevier, 1987
• Jahr Quelle: 2018
• Band/Heft Quelle: 123(2018), Seite 20-26
• ISSN Quelle: 1873-4596
• DOI: doi:10.1016/j.freeradbiomed.2018.05.065
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: 8-Isoprostane
• Sach-SW: Breast cancer
• Sach-SW: Cohort study
• Sach-SW: Colorectal cancer
• Sach-SW: Lung cancer
• Sach-SW: Neoplasms
• Sach-SW: Oxidative stress
• Sach-SW: Prostate cancer
• K10plus-PPN: 1576918637

Abstract

Background: Urinary 8‐isoprostane is an established biomarker for lipid peroxidation. However, the association between its pre-diagnostic levels and cancer incidence has rarely been evaluated. Methods: 8793 older adults from the German ESTHER cohort were followed up for cancer incidence by cancer registry data. A directed acyclic graph was utilized to identify potential confounders. Multivariate Cox regression models were applied to estimate hazard ratios (HRs) and 95% confidence intervals (95% CI). Results: During 14-year follow-up, 1540 incident cancer cases, including 207 lung, 196 colorectal, 218 breast and 245 prostate cancer cases were detected. 8-isoprostane concentrations were positively associated with lung cancer, but not with cancer at the other sites. The HR (95% CI) for the association with lung cancer was 1.61 (1.10, 2.34) for comparison of the top with bottom tertile in total population. The association of 8-isoprostane levels with lung cancer persisted after the adjustment for smoking and other potential confounders and was multiplicative to the effect of smoking. However, 8-isoprostane levels did not improve lung cancer prediction when added to a model containing age, sex and smoking. A protective association of increasing 8-isoprostane levels was observed for prostate cancer incidence but this association was only statistically significant among current smokers. Discussion: Our findings suggest that lipid peroxidation is involved in the development of lung cancer. However, high oxidative stress may be a protective factor for prostate cancer, especially among current smokers.