Status: Bibliographieeintrag
Standort: ---
Exemplare:
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Verfasst von: | Mostolizadeh, Reihaneh [VerfasserIn]  |
| Afsharnezhad, Zahra [VerfasserIn]  |
| Marciniak-Czochra, Anna [VerfasserIn]  |
Titel: | Mathematical model of chimeric anti-gene receptor (CAR) T cell therapy with presence of cytokine |
Verf.angabe: | Reihaneh Mostolizadeh, Zahra Afsharnezhad, Anna Marciniak-Czochra |
Umfang: | 18 S. |
Fussnoten: | Gesehen am 27.06.0218 |
Titel Quelle: | Enthalten in: Numerical algebra, control and optimization |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 8(2018), 1, S. 63-80 |
ISSN Quelle: | 2155-3297 |
Abstract: | In this paper, we reconstruct a mathematical model of therapy by CAR T cells for acute lymphoblastic leukemia (ALL) With injection of modified T cells to body, then some signs such as fever, nausea and etc appear. These signs occur for the sake of cytokine release syndrome (CRS). This syndrome has a direct effect on result and satisfaction of therapy. So, the presence of cytokine will be played an important role in modelling process of therapy (CAR T cells). Therefore, the model will include the CAR T cells, B healthy and cancer cells, other circulating lymphocytes in blood, and cytokine. We analyse stability conditions of therapy Without any control, the dynamic model evidences sub-clinical or clinical decay, chronic destabilization, singularity immediately after a few hours and finally, it depends on the initial conditions. Hence, we try to show by which conditions, therapy will be effective. For this aim, we apply optimal control theory. |
DOI: | doi:10.3934/naco.2018004 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Resolving-System: http://dx.doi.org/10.3934/naco.2018004 |
| DOI: https://doi.org/10.3934/naco.2018004 |
Sprache: | eng |
K10plus-PPN: | 1576927180 |
Verknüpfungen: | → Zeitschrift |
Mathematical model of chimeric anti-gene receptor (CAR) T cell therapy with presence of cytokine / Mostolizadeh, Reihaneh [VerfasserIn]
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