Comparison of auto-fluorescence and tetracycline fluorescence for guided bone surgery of medication-related osteonecrosis of the jaw

• Verfasst von: Ristow, Oliver [VerfasserIn]
• Verfasst von: Berger, Moritz [VerfasserIn]
• Verfasst von: Freudlsperger, Christian [VerfasserIn]
• Titel: Comparison of auto-fluorescence and tetracycline fluorescence for guided bone surgery of medication-related osteonecrosis of the jaw
• Titelzusatz: a randomized controlled feasibility study
• Verf.angabe: O. Ristow, S. Otto, C. Geiß, V. Kehl, M. Berger, M. Troeltzsch, S. Koerdt, B. Hohlweg-Majert, C. Freudlsperger, C. Pautke
• Jahr des Originals: 2016
• Umfang: 10 S.
• Fussnoten: Available online14 November 2016 ; Available online 14 November 2016 ; Gesehen am 28.06.2018
• Titel Quelle: Enthalten in: International journal of oral and maxillofacial surgery
• Jahr Quelle: 2017
• Band/Heft Quelle: 46(2017), 2, S. 157-166
• ISSN Quelle: 1399-0020
• DOI: doi:10.1016/j.ijom.2016.10.008
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1576934322

Abstract

Recent studies have indicated that bone shows auto-fluorescence under an appropriate fluorescence lamp. The aim of this preliminary study was to compare the success rates of the established tetracycline fluorescence-guided bone surgery with auto-fluorescence-guided bone surgery in the treatment of medication-related osteonecrosis of the jaw (MRONJ). Forty patients suffering from MRONJ were referred for surgical treatment and were divided randomly into two groups: auto-fluorescence (n=20) or tetracycline fluorescence (n=20) guided bone surgery. The primary endpoint was treatment success, defined as the absence of exposed bone at 8 weeks after surgery. Secondary outcomes assessed were mucosal integrity, signs of infection, pain, and loss of sensitivity; these were evaluated descriptively at 10 days, 8 weeks, 6 months, and 1 year after surgery. At 8 weeks postoperative, 18/20 patients (90%) in the auto-fluorescence group and 17/20 patients (85%) in the tetracycline fluorescence group showed mucosal integrity (P>0.05). At the last follow-up, 94% in the auto-fluorescence group and 89% in the tetracycline fluorescence group presented complete mucosal coverage with no exposed bone, infection, or pain (P>0.05). There was no significant difference between the two techniques for any of the secondary outcomes (P>0.05). The results of this preliminary study show that auto-fluorescence-guided bone surgery has comparable success rates to the established tetracycline fluorescence-guided bone surgery.