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Verfasst von:Brem, Silvia [VerfasserIn]   i
 Brandeis, Daniel [VerfasserIn]   i
Titel:Neuroimaging of cognitive brain function in paediatric obsessive compulsive disorder
Titelzusatz:a review of literature and preliminary meta-analysis
Verf.angabe:Silvia Brem, Tobias U. Hauser, Reto Iannaccone, Daniel Brandeis, Renate Drechsler, Susanne Walitza
Jahr:2012
Umfang:24 S.
Fussnoten:Published online: 8 June 2012 ; Gesehen am 28.06.2018
Titel Quelle:Enthalten in: Journal of neural transmission
Ort Quelle:Wien [u.a.] : Springer, 1950
Jahr Quelle:2012
Band/Heft Quelle:119(2012), 11, Seite 1425-1448
ISSN Quelle:1435-1463
Abstract:Obsessive compulsive disorder (OCD) is a frequent psychiatric disorder with a prevalence of 1-3 %, and it places an enormous burden on patients and their relatives. Up to 50 % of all cases suffer from onset in childhood or adolescence, and the disorder often takes a chronic course with a poor long-term prognosis. Paediatric OCD, with its high familiality, is often referred to as a distinct OCD subtype that coincides with a developmental period in which the prefrontal cortex exhibits extensive structural and functional maturation. In the present review, we included all studies examining cognitive brain activation in children and/or adolescents with OCD. We conducted extensive literature searches for relevant articles (Pubmed, ScienceDirect) and summarize, tabulate, and discuss their results. For the eight activation studies using functional magnetic resonance imaging, we also performed preliminary meta-analyses to assess the most consistent hypo- and hyperactivation in paediatric OCD patients during cognitive task performance. The review of literature as well as our preliminary meta-analyses of paediatric studies indicated altered functional activation in the same brain regions of affective and cognitive cortico-striatal-thalamic (CST) circuits as for adult OCD patients despite some variations in the direction of activation difference. The still small number of studies that examined brain activation in paediatric OCD patients thereby largely converged with previous findings in adult patients and with the established neurobiological models of CST circuit dysfunction in OCD.
DOI:doi:10.1007/s00702-012-0813-z
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1007/s00702-012-0813-z
 Volltext: https://link.springer.com/article/10.1007/s00702-012-0813-z
 DOI: https://doi.org/10.1007/s00702-012-0813-z
Datenträger:Online-Ressource
Sprache:eng
Bibliogr. Hinweis:Erscheint auch als : Druck-Ausgabe: Brem, Silvia, 1977 - : Neuroimaging of cognitive brain function in paediatric obsessive compulsive disorder. - 2012
K10plus-PPN:157693957X
Verknüpfungen:→ Zeitschrift

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