Effects of a preconditioning oral nutritional supplement on pig livers after warm ischemia

• Verfasst von: Nickkholgh, Arash [VerfasserIn]
• Verfasst von: Li, Zhanqing [VerfasserIn]
• Verfasst von: Liang, Rui [VerfasserIn]
• Verfasst von: Mikalauskas, Saulius [VerfasserIn]
• Verfasst von: Groß-Weissmann, Marie-Luise [VerfasserIn]
• Verfasst von: Zorn, Markus [VerfasserIn]
• Verfasst von: Büchler, Markus W. [VerfasserIn]
• Verfasst von: Schemmer, Peter [VerfasserIn]
• Titel: Effects of a preconditioning oral nutritional supplement on pig livers after warm ischemia
• Verf.angabe: Arash Nickkholgh, Zhanqing Li, Xue Yi, Elvira Mohr, Rui Liang, Saulius Mikalauskas, Marie-Luise Gross, Markus Zorn, Steffen Benzing, Heinz Schneider, Markus W. Büchler, and Peter Schemmer
• Fussnoten: Gesehen am 28.06.2018
• Titel Quelle: Enthalten in: HPB surgery
• Jahr Quelle: 2012
• Band/Heft Quelle: (2012) Artikel-Nummer 783479, 8 Seiten
• ISSN Quelle: 1607-8462
• DOI: doi:10.1155/2012/783479
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1576950085

Abstract

Several approaches have been proposed to pharmacologically ameliorate hepatic ischemia/reperfusion injury (IRI). This study was designed to evaluate the effects of a preconditioning oral nutritional supplement (pONS) containing glutamine, antioxidants, and green tea extract on hepatic warm IRI in pigs. Methods. pONS (70 g per serving, Fresenius Kabi, Germany) was dissolved in 250 mL tap water and given to pigs 24, 12, and 2 hrs before warm ischemia of the liver. A fourth dose was given 3 hrs after reperfusion. Controls were given the same amount of cellulose with the same volume of water. Two hours after the third dose of pONS, both the portal vein and the hepatic artery were clamped for 40 min. 0.5, 3, 6, and 8 hrs after reperfusion, heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), portal venous flow (PVF), hepatic arterial flow (HAF), bile flow, and transaminases were measured. Liver tissue was taken 8 hrs after reperfusion for histology and immunohistochemistry.