CNS macrophages control neurovascular development via CD95L

• Verfasst von: Chen, Si [VerfasserIn]
• Verfasst von: Tisch, Nathalie [VerfasserIn]
• Verfasst von: Yerbes, Rosario [VerfasserIn]
• Verfasst von: Ruiz de Almodóvar, Carmen [VerfasserIn]
• Titel: CNS macrophages control neurovascular development via CD95L
• Verf.angabe: Si Chen, Nathalie Tisch, Marcel Kegel, Rosario Yerbes, Robert Hermann, Hannes Hudalla, Cecilia Zuliani, Gülce Sila Gülcüler, Klara Zwadlo, Jakob von Engelhardt, Carmen Ruiz de Almodóvar and Ana Martin-Villalba
• Umfang: 16 S.
• Fussnoten: Available online 16 May 2017 ; Gesehen am 28.06.2018
• Titel Quelle: Enthalten in: Cell reports
• Jahr Quelle: 2017
• Band/Heft Quelle: 19(2017), 7, S. 1378-1393
• ISSN Quelle: 2211-1247
• DOI: doi:10.1016/j.celrep.2017.04.056
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1577000668

Abstract

Summary The development of neurons and vessels shares striking anatomical and molecular features, and it is presumably orchestrated by an overlapping repertoire of extracellular signals. CNS macrophages have been implicated in various developmental functions, including the morphogenesis of neurons and vessels. However, whether CNS macrophages can coordinately influence neurovascular development and the identity of the signals involved therein is unclear. Here, we demonstrate that activity of the cell surface receptor CD95 regulates neuronal and vascular morphogenesis in the post-natal brain and retina. Furthermore, we identify CNS macrophages as the main source of CD95L, and macrophage-specific deletion thereof reduces both neurovascular complexity and synaptic activity in the brain. CD95L-induced neuronal and vascular growth is mediated through src-family kinase (SFK) and PI3K signaling. Together, our study highlights a coordinated neurovascular development instructed by CNSmacrophage-derived CD95L, and it underlines the importance of macrophages for the establishment of the neurovascular network during CNS development.