Online-Ressource | |
Verfasst von: | Lee-Thedieck, Cornelia [VerfasserIn] |
Fiammengo, Roberto [VerfasserIn] | |
Spatz, Joachim P. [VerfasserIn] | |
Titel: | Impact of substrate elasticity on human hematopoietic stem and progenitor cell adhesion and motility |
Verf.angabe: | Cornelia Lee-Thedieck, Nicole Rauch, Roberto Fiammengo, Gerd Klein and Joachim P. Spatz |
Umfang: | 11 S. |
Fussnoten: | Published online October 1, 2012 ; Gesehen am 28.06.2018 |
Titel Quelle: | Enthalten in: Journal of cell science |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 125(2012), 16, S. 3765-3775 |
ISSN Quelle: | 1477-9137 |
Abstract: | In the bone marrow, hematopoietic stem cells (HSCs) reside in endosteal and vascular niches. The interactions with the niches are essential for the maintenance of HSC number and properties. Although the molecular nature of these interactions is well understood, little is known about the role of physical parameters such as matrix elasticity. Osteoblasts, the major cellular component of the endosteal HSC niche, flatten during HSC mobilization. We show that this process is accompanied by osteoblast stiffening, demonstrating that not only biochemical signals but also mechanical properties of the niche are modulated. HSCs react to stiffer substrates with increased cell adhesion and migration, which could facilitate the exit of HSCs from the niche. These results indicate that matrix elasticity is an important factor in regulating the retention of HSCs in the endosteal niche and should be considered in attempts to propagate HSCs in vitro for clinical applications. |
DOI: | doi:10.1242/jcs.095596 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt. Kostenfrei: Verlag: http://dx.doi.org/10.1242/jcs.095596 |
Kostenfrei: Verlag: http://jcs.biologists.org/content/125/16/3765 | |
DOI: https://doi.org/10.1242/jcs.095596 | |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1577015096 |
Verknüpfungen: | → Zeitschrift |