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Verfasst von:Fischer, Christian [VerfasserIn]   i
 Schmidmaier, Gerhard [VerfasserIn]   i
 Doll, Julian [VerfasserIn]   i
 Grützner, Paul Alfred [VerfasserIn]   i
 Moghaddam-Alvandi, Arash [VerfasserIn]   i
Titel:Safety study
Titelzusatz:is there a pathologic IGF-1, PDGF and TGF-β cytokine expression caused by adjunct BMP-7 in tibial and femoral non-union therapy?
Verf.angabe:Christian Fischer, Christian Reiner, Gerhard Schmidmaier, Julian Doll, Christopher Child, Paul Alfred Grützner, Bahram Biglari, Sonja Boxriker, Arash Moghaddam
Umfang:7 S.
Fussnoten:Published 16 April 2018 ; Gesehen am 29.06.2018
Titel Quelle:Enthalten in: Therapeutics and clinical risk management
Jahr Quelle:2018
Band/Heft Quelle:14(2018), S. 691-697
ISSN Quelle:1178-203X
Abstract:Background: In this prospective safety study, we investigated if the characteristic cytokine expression during bone regeneration is manipulated by the local application of bone morphogenetic protein-7 (BMP-7) in non-union surgery. Therefore, the levels of insulin like growth factor 1 (IGF-1), platelet-derived growth factor AB (PDGF-AB) and transforming growth factor beta (TGF-β) were compared between patients with the gold standard use of autologous bone graft (ABG) and those with additional application of BMP-7 as part of the diamond concept.Patients and methods: Between 2009 and 2014, of the 153 patients with tibial and femoral non-unions, a matched pair analysis was performed to compare the serological cytokine expressions. Blood samples were collected preoperatively, 1, 2 and 6 weeks as well as 3 and 6 months after non-union surgery. Matching criteria were smoking status, fracture location, gender, age and body mass index (BMI). Patients in G1 (n=10) were treated with ABG and local BMP-7 while their matching partners in G2 (n=10) received ABG only. The routine clinical and radiologic follow-up was 1 year.Results: Although the IGF-1 quantification in G2 showed higher pre- and postoperative values compared to G1 (p
DOI:doi:10.2147/TCRM.S160064
URL:Kostenfrei: Verlag: http://dx.doi.org/10.2147/TCRM.S160064
 Kostenfrei: Verlag: https://www.dovepress.com/safety-study-is-there-a-pathologic-igf-1-pdgf-and-tgf-beta-cytokine-e-peer-reviewed-article-TC ...
 DOI: https://doi.org/10.2147/TCRM.S160064
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1577045769
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