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| Online-Ressource |
Verfasst von: | Fischer, Christian [VerfasserIn]  |
| Schmidmaier, Gerhard [VerfasserIn]  |
| Doll, Julian [VerfasserIn]  |
| Grützner, Paul Alfred [VerfasserIn]  |
| Moghaddam-Alvandi, Arash [VerfasserIn]  |
Titel: | Safety study |
Titelzusatz: | is there a pathologic IGF-1, PDGF and TGF-β cytokine expression caused by adjunct BMP-7 in tibial and femoral non-union therapy? |
Verf.angabe: | Christian Fischer, Christian Reiner, Gerhard Schmidmaier, Julian Doll, Christopher Child, Paul Alfred Grützner, Bahram Biglari, Sonja Boxriker, Arash Moghaddam |
Umfang: | 7 S. |
Fussnoten: | Published 16 April 2018 ; Gesehen am 29.06.2018 |
Titel Quelle: | Enthalten in: Therapeutics and clinical risk management |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 14(2018), S. 691-697 |
ISSN Quelle: | 1178-203X |
Abstract: | Background: In this prospective safety study, we investigated if the characteristic cytokine expression during bone regeneration is manipulated by the local application of bone morphogenetic protein-7 (BMP-7) in non-union surgery. Therefore, the levels of insulin like growth factor 1 (IGF-1), platelet-derived growth factor AB (PDGF-AB) and transforming growth factor beta (TGF-β) were compared between patients with the gold standard use of autologous bone graft (ABG) and those with additional application of BMP-7 as part of the diamond concept.Patients and methods: Between 2009 and 2014, of the 153 patients with tibial and femoral non-unions, a matched pair analysis was performed to compare the serological cytokine expressions. Blood samples were collected preoperatively, 1, 2 and 6 weeks as well as 3 and 6 months after non-union surgery. Matching criteria were smoking status, fracture location, gender, age and body mass index (BMI). Patients in G1 (n=10) were treated with ABG and local BMP-7 while their matching partners in G2 (n=10) received ABG only. The routine clinical and radiologic follow-up was 1 year.Results: Although the IGF-1 quantification in G2 showed higher pre- and postoperative values compared to G1 (p |
DOI: | doi:10.2147/TCRM.S160064 |
URL: | Kostenfrei: Verlag: http://dx.doi.org/10.2147/TCRM.S160064 |
| Kostenfrei: Verlag: https://www.dovepress.com/safety-study-is-there-a-pathologic-igf-1-pdgf-and-tgf-beta-cytokine-e-peer-reviewed-article-TC ... |
| DOI: https://doi.org/10.2147/TCRM.S160064 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1577045769 |
Verknüpfungen: | → Zeitschrift |
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Lokale URL UB: | Zum Volltext |
Safety study / Fischer, Christian [VerfasserIn] (Online-Ressource)
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