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Verfasst von:Seiffert, Martina [VerfasserIn]   i
 Dietrich, Sascha [VerfasserIn]   i
 Jethwa, Alexander [VerfasserIn]   i
 Glimm, Hanno [VerfasserIn]   i
 Lichter, Peter [VerfasserIn]   i
 Zenz, Thorsten [VerfasserIn]   i
Titel:Exploiting biological diversity and genomic aberrations in chronic lymphocytic leukemia
Verf.angabe:Martina Seiffert, Sascha Dietrich, Alexander Jethwa, Hanno Glimm, Peter Lichter and Thorsten Zenz
Jahr:2012
Jahr des Originals:2011
Umfang:9 S.
Fussnoten:Published online: 06 Dec 2011 ; Gesehen am 29.06.2018
Titel Quelle:Enthalten in: Leukemia and lymphoma
Ort Quelle:London [u.a.] : Taylor & Francis Group, 1989
Jahr Quelle:2012
Band/Heft Quelle:53(2012), 6, Seite 1023-1031
ISSN Quelle:1029-2403
Abstract:There is remarkable heterogeneity in the clinical course and biological characteristics of patient subgroups with chronic lymphocytic leukemia (CLL). Mutations of key tumor suppressors (ATM, miR-15a/16-1 and TP53) have been identified in CLL, and these aberrations are important “drivers” of the disease and some of its clinical characteristics. While some mutations are associated with poor outcome [particularly del(17p) and TP53 mutation], others are linked to a favorable clinical course [e.g. del(13q) as sole aberration]. In addition to genetic aberrations, antigen drive and microenvironmental interactions contribute to the pathogenesis of CLL. How the genetic aberrations impact on the process of antigen drive or microenvironmental interactions is currently unclear. Our improved understanding of the biology and clinical course of specific genetic subgroups is beginning to be translated into more specific and targeted treatment approaches. As a result, genetic subgroups are treated in distinct protocols. This review summarizes the contribution of the microenvironment and the most important genetic aberrations in CLL and how our improved knowledge of the biology of CLL may translate into improved treatment results.
DOI:doi:10.3109/10428194.2011.631638
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.3109/10428194.2011.631638
 Volltext: https://doi.org/10.3109/10428194.2011.631638
 DOI: https://doi.org/10.3109/10428194.2011.631638
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:chronic lymphocytic leukemia
 cytogenetics
 drug resistance
 Lymphocytes
 microenvironment
 molecular genetics
K10plus-PPN:1577046935
Verknüpfungen:→ Zeitschrift

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