malERA

• Verfasst von: Kaslow, David C. [VerfasserIn]
• Verfasst von: Leroy, Odile [VerfasserIn]
• Titel: malERA
• Titelzusatz: an updated research agenda for diagnostics, drugs, vaccines, and vector control in malaria elimination and eradication
• Verf.angabe: The malERA Refresh Consultative Panel on Tools for Malaria Elimination. Members of the Writing Group: David C. Kaslow, Fredos Okumu, Timothy N.C. Wells, Regina Rabinovich. Members of the MESA malERA Refresh Tools for Malaria Elimination Panel: u.a. Odile Leroy
• E-Jahr: 2017
• Jahr: November 30, 2017
• Umfang: 35 S.
• Fussnoten: Gesehen am 02.07.2018
• Titel Quelle: Enthalten in: Public Library of SciencePLoS medicine
• Ort Quelle: Lawrence, Kan. : PLoS, 2004
• Jahr Quelle: 2017
• Band/Heft Quelle: 14(2017,11) Artikel-Nummer e1002455, 35 Seiten
• ISSN Quelle: 1549-1676
• DOI: doi:10.1371/journal.pmed.1002455
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Antimalarials
• Sach-SW: Drug research and development
• Sach-SW: Infectious disease control
• Sach-SW: Malaria
• Sach-SW: Malarial parasites
• Sach-SW: Parasitic diseases
• Sach-SW: Plasmodium
• Sach-SW: Vaccines
• K10plus-PPN: 1577088077

Abstract

Since the turn of the century, a remarkable expansion has been achieved in the range and effectiveness of products and strategies available to prevent, treat, and control malaria, including advances in diagnostics, drugs, vaccines, and vector control. These advances have once again put malaria elimination on the agenda. However, it is clear that even with the means available today, malaria control and elimination pose a formidable challenge in many settings. Thus, currently available resources must be used more effectively, and new products and approaches likely to achieve these goals must be developed. This paper considers tools (both those available and others that may be required) to achieve and maintain malaria elimination. New diagnostics are needed to direct treatment and detect transmission potential; new drugs and vaccines to overcome existing resistance and protect against clinical and severe disease, as well as block transmission and prevent relapses; and new vector control measures to overcome insecticide resistance and more powerfully interrupt transmission. It is also essential that strategies for combining new and existing approaches are developed for different settings to maximise their longevity and effectiveness in areas with continuing transmission and receptivity. For areas where local elimination has been recently achieved, understanding which measures are needed to maintain elimination is necessary to prevent rebound and the reestablishment of transmission. This becomes increasingly important as more countries move towards elimination.