| |  Online-Ressource |
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| Verfasst von: | Bröker-Lai, Jenny [VerfasserIn]  |
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| | Kollewe, Astrid [VerfasserIn] |
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| | Schindeldecker, Barbara [VerfasserIn] |
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| | Pohle, Jörg [VerfasserIn] |
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| | Nguyen Chi, Vivan [VerfasserIn] |
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| | Mathar, Ilka [VerfasserIn] |
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| | Guzman, Raul [VerfasserIn] |
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| | Schwarz, Yvonne [VerfasserIn] |
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| | Lai, Chung Lun Alan [VerfasserIn] |
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| | Weißgerber, Petra [VerfasserIn] |
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| | Schwegler, Herbert [VerfasserIn] |
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| | Dietrich, Alexander [VerfasserIn] |
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| | Both, Martin [VerfasserIn] |
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| | Sprengel, Rolf [VerfasserIn] |
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| | Draguhn, Andreas [VerfasserIn] |
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| | Koehr, Georg [VerfasserIn] |
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| | Fakler, Bernd [VerfasserIn] |
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| | Flockerzi, Veit [VerfasserIn] |
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| | Bruns, Dieter [VerfasserIn] |
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| | Freichel, Marc [VerfasserIn] |
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| Titel: | Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory |
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| Verf.angabe: | Jenny Bröker‐Lai, Astrid Kollewe, Barbara Schindeldecker, Jörg Pohle, Vivan Nguyen Chi, Ilka Mathar, Raul Guzman, Yvonne Schwarz, Alan Lai, Petra Weißgerber, Herbert Schwegler, Alexander Dietrich, Martin Both, Rolf Sprengel, Andreas Draguhn, Georg Köhr, Bernd Fakler, Veit Flockerzi, Dieter Bruns and Marc Freichel |
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| Jahr: | 2017 |
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| Umfang: | 20 S. |
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| Fussnoten: | Online veröffentlicht: 8 August 2017 ; Gesehen am 16.12.2024 |
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| Titel Quelle: | Enthalten in: European Molecular Biology OrganizationThe EMBO journal |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 1982 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 36(2017), 18 vom: Sept., Seite 2770-2789 |
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| ISSN Quelle: | 1460-2075 |
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| Abstract: | Canonical transient receptor potential (TRPC) channels influence various neuronal functions. Using quantitative high‐resolution mass spectrometry, we demonstrate that TRPC1, TRPC4, and TRPC5 assemble into heteromultimers with each other, but not with other TRP family members in the mouse brain and hippocampus. In hippocampal neurons from Trpc1/Trpc4/Trpc5‐triple‐knockout (Trpc1/4/5−/−) mice, lacking any TRPC1‐, TRPC4‐, or TRPC5‐containing channels, action potential‐triggered excitatory postsynaptic currents (EPSCs) were significantly reduced, whereas frequency, amplitude, and kinetics of quantal miniature EPSC signaling remained unchanged. Likewise, evoked postsynaptic responses in hippocampal slice recordings and transient potentiation after tetanic stimulation were decreased. In vivo, Trpc1/4/5−/− mice displayed impaired cross‐frequency coupling in hippocampal networks and deficits in spatial working memory, while spatial reference memory was unaltered. Trpc1/4/5−/− animals also exhibited deficiencies in adapting to a new challenge in a relearning task. Our results indicate the contribution of heteromultimeric channels from TRPC1, TRPC4, and TRPC5 subunits to the regulation of mechanisms underlying spatial working memory and flexible relearning by facilitating proper synaptic transmission in hippocampal neurons. |
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| DOI: | doi:10.15252/embj.201696369 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.15252/embj.201696369 |
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| | kostenfrei: Volltext: https://www.embopress.org/doi/full/10.15252/embj.201696369 |
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| | Volltext: http://dx.doi.org/10.15252/embj.201696369 |
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| | Volltext: http://emboj.embopress.org/content/36/18/2770 |
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| | DOI: https://doi.org/10.15252/embj.201696369 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cross‐frequency coupling |
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| | hippocampal synaptic transmission |
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| | relearning |
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| | spatial working memory |
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| | TRPC1/C4/C5 heteromeric assembly |
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| K10plus-PPN: | 157713608X |
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| Verknüpfungen: | → Zeitschrift |
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Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory / Bröker-Lai, Jenny [VerfasserIn]; 2017 (Online-Ressource)
