Diabetes mellitus and bone metabolism

• Verfasst von: Kasperk, Christian [VerfasserIn]
• Verfasst von: Georgescu, Carmen [VerfasserIn]
• Verfasst von: Nawroth, Peter Paul [VerfasserIn]
• Titel: Diabetes mellitus and bone metabolism
• Verf.angabe: Christian Kasperk, Carmen Georgescu, Peter Nawroth
• Jahr: 2017
• Umfang: 5 S.
• Fussnoten: Publikationsdatum: 10.Januar 2017 (eFirst) ; Gesehen am 02.07.2018
• Titel Quelle: Enthalten in: Experimental and clinical endocrinology & diabetes
• Ort Quelle: Stuttgart [u.a.] : Thieme, 1983
• Jahr Quelle: 2017
• Band/Heft Quelle: 125(2017), 4, Seite 213-217
• ISSN Quelle: 1439-3646
• DOI: doi:10.1055/s-0042-123036
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1577137825

Abstract

Diabetes mellitus and bone metabolism affect mesenchymal tissues and have numerous epidemiological and pathophysiological associations in common. Diabetes mellitus affects bone metabolism and increases fracture risk. The pathophysiological mechanims how type 1 and type 2 diabetes impair bone metabolism and bone strength may differ which is outlined in this review. Direct metabolic effects in additon to centrally controlled endocrine loops exert suppressive effects on bone formation and may also stimulate bone Resorption. Decreased bone formation in combination with increased bone resorption strongly increases fracture risk.</p>