Stress propagation through biological lipid bilayers in silico

• Verfasst von: Aponte-Santamaria, Camilo [VerfasserIn]
• Verfasst von: Brunken, Jan [VerfasserIn]
• Verfasst von: Gräter, Frauke [VerfasserIn]
• Titel: Stress propagation through biological lipid bilayers in silico
• Verf.angabe: Camilo Aponte-Santamaría, Jan Brunken and Frauke Gräter
• E-Jahr: 2017
• Jahr: 4 October 2017
• Umfang: 4 S.
• Fussnoten: Published online 30 August 2017 ; Gesehen am 02.07.2018
• Titel Quelle: Enthalten in: American Chemical SocietyJournal of the American Chemical Society
• Ort Quelle: Washington, DC : American Chemical Society, 1879
• Jahr Quelle: 2017
• Band/Heft Quelle: 139(2017), 39, Seite 13588-13591
• ISSN Quelle: 1520-5126
• DOI: doi:10.1021/jacs.7b04724
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: 1,2-Dipalmitoylphosphatidylcholine
• Sach-SW: Computer Simulation
• Sach-SW: Lipid Bilayers
• Sach-SW: Molecular Dynamics Simulation
• Sach-SW: Stress, Mechanical
• K10plus-PPN: 1577137868

Abstract

Membrane tension plays various critical roles in the cell. We here asked how fast and how far localized pulses of mechanical stress dynamically propagate through biological lipid bilayers. In both coarse-grained and all-atom molecular dynamics simulations of a dipalmitoylphosphatidylcholine lipid bilayer, we observed nanometer-wide stress pulses, propagating very efficiently longitudinally at a velocity of approximately 1.4 ± 0.5 nm/ps (km/s), in close agreement with the expected speed of sound from experiments. Remarkably, the predicted characteristic attenuation time of the pulses was in the order of tens of picoseconds, implying longitudinal stress propagation over length scales up to several tens of nanometers before damping. Furthermore, the computed dispersion relation leading to such damping was consistent with proposed continuum viscoelastic models of propagation. We suggest this mode of stress propagation as a potential ultrafast mechanism of signaling that may quickly couple mechanosensitive elements in crowded biological membranes.