Omega-6 fatty acids

• Verfasst von: Delgado Gonzales de Kleber, Graciela [VerfasserIn]
• Verfasst von: März, Winfried [VerfasserIn]
• Verfasst von: Kleber, Marcus E. [VerfasserIn]
• Titel: Omega-6 fatty acids
• Titelzusatz: opposing associations with risk : the Ludwigshafen Risk and Cardiovascular Health Study
• Verf.angabe: Graciela E. Delgado, MSc, Winfried März, MD, Stefan Lorkowski, PhD, Clemens von Schacky, MD, Marcus E. Kleber, PhD
• Jahr: 2017
• Umfang: 23 S.
• Fussnoten: Available online 1 June 2017 ; Gesehen am 02.07.2018
• Titel Quelle: Enthalten in: Journal of clinical lipidology
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 2007
• Jahr Quelle: 2017
• Band/Heft Quelle: 11(2017), 4, Seite 1082-1090.e14
• ISSN Quelle: 1876-4789
• DOI: doi:10.1016/j.jacl.2017.05.003
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Risk factors
• Sach-SW: Arachidonic acid
• Sach-SW: Linoleic acid
• Sach-SW: Mortality
• Sach-SW: Nutrition
• Sach-SW: Omega-6 fatty acids
• K10plus-PPN: 1577188365

Abstract

Background: Omega-6 polyunsaturated fatty acids (omega-6 PUFA) are recommended in European cardiovascular prevention guidelines. However, individual fatty acids have distinct biological functions, and there have been conflicting reports about the association of omega-6 PUFA with cardiovascular risk. Objective: The aim of our study was to investigate the association of individual omega-6 fatty acids with mortality in a cohort of patients referred for coronary angiography. Methods: Omega-6 PUFA proportions were measured in erythrocytes at baseline in a total of 3259 patients participating in the Ludwigshafen Risk and Cardiovascular Health Study using the HS-Omega-3 Index method. Associations of omega-6 PUFA with mortality were analyzed by Cox regression with adjustment for conventional risk factors. Results: During a median follow-up of 10.0 years, 975 patients (29.9%) died, 614 patients (18.8%) from cardiovascular causes. γ-Linolenic acid was inversely associated with all-cause and cardiovascular mortalities in models adjusted for cardiovascular risk factors with hazard ratios of 0.88 (0.82-0.95) and 0.86 (0.79-0.95) per 1-standard deviation increase, respectively. Adrenic acid and docosapentaenoic acid ω-6 were both directly associated with risk with hazard ratio of 1.10 (1.30-1.18) and 1.12 (1.05-1.19) for all-cause mortality, respectively. No association was found for arachidonic acid. Conclusions: We observed opposing associations of individual omega-6 PUFA with mortality risk. While LA and γ-linolenic acid were associated with reduced risk, there was a direct association for adrenic acid and docosapentaenoic acid. These differences do not support the use of omega-6 PUFA concentrations as a single combined metric, and the prognostic value of each individual member should be examined separately.