| Online-Ressource |
Verfasst von: | Schnülle, Peter [VerfasserIn]  |
| Mundt, Heiko [VerfasserIn]  |
| Drüschler, Felix [VerfasserIn]  |
| Schmitt, Wilhelm [VerfasserIn]  |
| Yard, Benito A. [VerfasserIn]  |
| Krämer, Bernhard [VerfasserIn]  |
| Benck, Urs Tobias [VerfasserIn]  |
Titel: | Impact of spontaneous donor hypothermia on graft outcomes after kidney transplantation |
Verf.angabe: | P. Schnuelle, H.M. Mundt, F. Drüschler, W.H. Schmitt, B.A. Yard, B.K. Krämer, U. Benck |
Jahr: | 2018 |
Jahr des Originals: | 2017 |
Umfang: | 11 S. |
Fussnoten: | Gesehen am 04.07.2018 |
Titel Quelle: | Enthalten in: American journal of transplantation |
Ort Quelle: | [Amsterdam] : Elsevier, 2001 |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 18(2018), 3, Seite 704-714 |
ISSN Quelle: | 1600-6143 |
Abstract: | A previous donor intervention trial found that therapeutic hypothermia reduced delayed graft function (DGF) after kidney transplantation. This retrospective cohort study nested in the randomized dopamine trial (ClinicalTrials.gov identifier: NCT000115115) investigates the effects of spontaneous donor hypothermia (core body temperature <36°C) on initial kidney graft function, and evaluates 5-year graft survival. Hypothermia assessed by a singular measurement in the intensive care unit 4-20 hours before procurement was associated with less DGF after kidney transplantation (odds ratio [OR] 0.56, 95% confidence interval [CI] 0.34-0.91). The benefit was greater when need for more than a single posttransplant dialysis session was analyzed (OR 0.48, 95%CI 0.28-0.82). Donor dopamine ameliorated dialysis requirement independently from hypothermia in a temporal relationship with exposure (OR 0.93, 95%CI 0.87-0.98, per hour). A lower core body temperature in the donor was associated with lower serum creatinine levels before procurement, which may reflect lower systemic inflammation and attenuated renal injury from brain death. Despite a considerable effect on DGF, our study failed to demonstrate a graft survival advantage (hazard ratio [HR] 0.83, 95%CI 0.54-1.27), whereas dopamine treatment was associated with improved long-term outcome (HR 0.95, 95%CI 0.91-0.99 per hour). |
DOI: | doi:10.1111/ajt.14541 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1111/ajt.14541 |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ajt.14541 |
| DOI: https://doi.org/10.1111/ajt.14541 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | clinical research/practice |
| delayed graft function (DGF) |
| donors and donation: donation after brain death (DBD) |
| graft survival |
| kidney (allograft) function/dysfunction |
| kidney transplantation/nephrology |
| organ procurement |
| organ procurement and allocation |
K10plus-PPN: | 1577261461 |
Verknüpfungen: | → Zeitschrift |
Impact of spontaneous donor hypothermia on graft outcomes after kidney transplantation / Schnülle, Peter [VerfasserIn]; 2018 (Online-Ressource)