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Verfasst von:Cheng, Jie [VerfasserIn]   i
 Tang, Qiuqiong [VerfasserIn]   i
 Cao, Xue [VerfasserIn]   i
 Burwinkel, Barbara [VerfasserIn]   i
Titel:Cell-free circulating DNA integrity based on peripheral blood as a biomarker for diagnosis of cancer
Titelzusatz:a systematic review
Verf.angabe:Jie Cheng, Qiuqiong Tang, Xue Cao, and Barbara Burwinkel
Umfang:8 S.
Fussnoten:Published onlinefirst August 22, 2017 ; Gesehen am 04.07.2018
Titel Quelle:Enthalten in: Cancer epidemiology, biomarkers & prevention
Jahr Quelle:2017
Band/Heft Quelle:26(2017), 11, S. 1595-1602
ISSN Quelle:1538-7755
Abstract:Background: Cell-free DNA integrity (cfDI) has been identified as a potential diagnostic biomarker for different types of cancer, suggesting the importance of liquid biopsy. Methods: This systematic review aims to assess the diagnostic performance of cfDI in cancer. After an extensive search of literature published through February 28, 2017, 25 articles that included 40 studies were identified. The descriptions of all the studies were analyzed. The sensitivity, specificity, positive and negative likelihood ratios, diagnostic ORs, weighted symmetric summary receiver operating characteristic curve, and the area under the curve (AUC) of cfDI in these studies were calculated. Results: Aberrant results of cfDI were observed. Some studies observed an increased cfDI in cancer patients, while some studies confirmed a decreased cfDI compared with healthy or benign controls. Conclusions: This review suggests that cfDI is controversial as a blood-based biomarker of cancers, although thesensitivity and AUC were relatively high. Impact: cfDI shows heterogeneity between different studies; more perspective studies are needed to further assess its diagnostic performance, especially with other markers in combination. Cancer Epidemiol Biomarkers Prev; 26(11); 1595-602. ©2017 AACR.
DOI:doi:10.1158/1055-9965.EPI-17-0502
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Kostenfrei: Verlag: http://dx.doi.org/10.1158/1055-9965.EPI-17-0502
 Kostenfrei: Verlag: http://cebp.aacrjournals.org/content/26/11/1595
 DOI: https://doi.org/10.1158/1055-9965.EPI-17-0502
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1577266730
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