| |  Online-Ressource |
|---|
| Verfasst von: | Seleit, Ali [VerfasserIn]  |
|---|
| | Krämer, Isabel [VerfasserIn] |
|---|
| | Riebesehl, Bea [VerfasserIn] |
|---|
| | Ambrosio, Elizabeth [VerfasserIn] |
|---|
| | Stolper, Julian [VerfasserIn] |
|---|
| | Lischik, Colin Q. [VerfasserIn] |
|---|
| | Dross, Nicolas [VerfasserIn] |
|---|
| | Centanin, Lázaro [VerfasserIn] |
|---|
| Titel: | Neural stem cells induce the formation of their physical niche during organogenesis |
|---|
| Verf.angabe: | Ali Seleit, Isabel Krämer, Bea F Riebesehl, Elizabeth M Ambrosio, Julian S Stolper, Colin Q Lischik, Nicolas Dross, Lazaro Centanin |
|---|
| E-Jahr: | 2017 |
|---|
| Jahr: | 27 September 2017 |
|---|
| Umfang: | 30 S. |
|---|
| Fussnoten: | Gesehen am 04.07.2018 |
|---|
| Titel Quelle: | Enthalten in: eLife |
|---|
| Ort Quelle: | Cambridge : eLife Sciences Publications, 2012 |
|---|
| Jahr Quelle: | 2017 |
|---|
| Band/Heft Quelle: | 6(2017) Artikel-Nummer e29173, 30 Seiten |
|---|
| ISSN Quelle: | 2050-084X |
|---|
| Abstract: | Most organs rely on stem cells to maintain homeostasis during post-embryonic life. Typically, stem cells of independent lineages work coordinately within mature organs to ensure proper ratios of cell types. Little is known, however, on how these different stem cells locate to forming organs during development. Here we show that neuromasts of the posterior lateral line in medaka are composed of two independent life-long lineages with different embryonic origins. Clonal analysis and 4D imaging revealed a hierarchical organisation with instructing and responding roles: an inner, neural lineage induces the formation of an outer, border cell lineage (nBC) from the skin epithelium. Our results demonstrate that the neural lineage is necessary and sufficient to generate nBCs highlighting self-organisation principles at the level of the entire embryo. We hypothesise that induction of surrounding tissues plays a major role during the establishment of vertebrate stem cell niches. |
|---|
| DOI: | doi:10.7554/eLife.29173 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Kostenfrei: Volltext ; Verlag: http://dx.doi.org/10.7554/eLife.29173 |
|---|
| | Kostenfrei: Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617629/ |
|---|
| | DOI: https://doi.org/10.7554/eLife.29173 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| K10plus-PPN: | 1577279956 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Neural stem cells induce the formation of their physical niche during organogenesis / Seleit, Ali [VerfasserIn]; 27 September 2017 (Online-Ressource)
