L1CAM in the early enteric and urogenital system

• Verfasst von: Pechriggl, Elisabeth Judith [VerfasserIn]
• Verfasst von: Altevogt, Peter [VerfasserIn]
• Titel: L1CAM in the early enteric and urogenital system
• Verf.angabe: Elisabeth Judith Pechriggl, Nicole Concin, Michael J. Blumer, Mario Bitsche, Marit Zwierzina, Jozsef Dudas, Katarzyna Koziel, Peter Altevogt, Alain-Gustave Zeimet, Helga Fritsch
• Jahr: 2017
• Umfang: 12 S.
• Fussnoten: Published online: November 8, 2016 ; Gesehen am 05.07.2018
• Titel Quelle: Enthalten in: Journal of histochemistry & cytochemistry
• Ort Quelle: London [u.a.] : Sage Publ., 1953
• Jahr Quelle: 2017
• Band/Heft Quelle: 65(2017), 1, Seite 21-32
• ISSN Quelle: 1551-5044
• DOI: doi:10.1369/0022155416677241
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1577307259

Abstract

L1 cell adhesion molecule (L1CAM) is a transmembrane molecule belonging to the L1 protein family. It has shown to be a key player in axonal guidance in the course of neuronal development. Furthermore, L1CAM is also crucial for the establishment of the enteric and urogenital organs and is aberrantly expressed in cancer originating in these organs. Carcinogenesis and embryogenesis follow a lot of similar molecular pathways, but unfortunately, comprehensive data on L1CAM expression and localization in human developing organs are lacking so far. In the present study we, therefore, examined the spatiotemporal distribution of L1CAM in the early human fetal period (weeks 8-12 of gestation) by means of immunohistochemistry and in situ hybridization (ISH). In the epithelia of the gastrointestinal organs, L1CAM localization cannot be observed in the examined stages most likely due to their advanced polarization and differentiation. Despite these results, our ISH data indicate weak L1CAM expression, but only in few epithelial cells. The genital tracts, however, are distinctly L1CAM positive throughout the entire fetal period. We, therefore, conclude that in embryogenesis L1CAM is crucial for further differentiation of epithelia., L1 cell adhesion molecule (L1CAM) is a transmembrane molecule belonging to the L1 protein family. It has shown to be a key player in axonal guidance in the course of neuronal development. Furthermore, L1CAM is also crucial for the establishment of the enteric and urogenital organs and is aberrantly expressed in cancer originating in these organs. Carcinogenesis and embryogenesis follow a lot of similar molecular pathways, but unfortunately, comprehensive data on L1CAM expression and localization in human developing organs are lacking so far. In the present study we, therefore, examined the spatiotemporal distribution of L1CAM in the early human fetal period (weeks 8-12 of gestation) by means of immunohistochemistry and in situ hybridization (ISH). In the epithelia of the gastrointestinal organs, L1CAM localization cannot be observed in the examined stages most likely due to their advanced polarization and differentiation. Despite these results, our ISH data indicate weak L1CAM expression, but only in few epithelial cells. The genital tracts, however, are distinctly L1CAM positive throughout the entire fetal period. We, therefore, conclude that in embryogenesis L1CAM is crucial for further differentiation of epithelia.