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Status: Bibliographieeintrag

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Verfasst von:Takeichi, Takayuki [VerfasserIn]   i
 Mocevičius, Paulius [VerfasserIn]   i
 Deduchovas, Olegas [VerfasserIn]   i
 Salnikova, Olga [VerfasserIn]   i
 Castro Santa, Edward [VerfasserIn]   i
 Büchler, Markus W. [VerfasserIn]   i
 Schmidt, Jan [VerfasserIn]   i
 Ryschich, Eduard [VerfasserIn]   i
Titel:αLβ2 integrin is indispensable for CD8+ T-cell recruitment in experimental pancreatic and hepatocellular cancer
Verf.angabe:Takayuki Takeichi, Paulius Mocevicius, Olegas Deduchovas, Olga Salnikova, Edward Castro‐Santa, Markus W. Büchler, Jan Schmidt and Eduard Ryschich
Jahr:2012
Umfang:10 S.
Fussnoten:First published: 06 June 2011 ; Im Titel ist das "+"-Zeichen hochgestellt, "L" tiefgestellt ; Gesehen am 05.07.2018
Titel Quelle:Enthalten in: International journal of cancer
Ort Quelle:Bognor Regis : Wiley-Liss, 1966
Jahr Quelle:2012
Band/Heft Quelle:130(2012), 9, Seite 2067-2076
ISSN Quelle:1097-0215
Abstract:Recruitment of activated leukocytes from peripheral blood into the tumor tissue is a crucial step of the immune response, which is controlled by the interaction between specific adhesion molecules such as endothelial ICAM-1 and leukocyte β2-integrins. Although attenuated expression of adhesion molecules on tumor endothelium has been proposed to represent a mechanism, which suppresses the intratumoral leukocyte infiltration, the relevance of adhesion molecules for leukocyte recruitment in tumor tissue is poorly understood. The present study is the first investigation of the role of ICAM-1 and β2-integrins in leukocyte recruitment in pancreatic and hepatocellular cancer in vivo, which was studied using knockout mice, intravital time-lapse microscopy and immunohistochemistry. We found that tumor tissue of both pancreatic and hepatocellular cancer was infiltrated with numerous active lymphoid and myeloid leukocytes, although the leukocyte extravasation rate in tumor blood vessels was very low. The knockout of LFA-1 (also known as αLβ2 integrin) strongly suppressed recruitment of CD8+ T cells whereas no significant differences of leukocyte adhesion and infiltration were found in ICAM-1−/− and Mac-1−/− mice. Analysis of the interstitial leukocyte migration demonstrated that intratumoral leukocytes used haptokinetic type of migration, however, no significant differences of leukocyte migration between any knockout strains were found. We concluded that leukocyte recruitment in pancreatic and hepatocellular cancer is a slow-going process whose dynamics clearly contrasts to a high-speed leukocyte recruitment during acute inflammation. In contrast to acute inflammatory reaction, only LFA-1 controls recruitment of CD8+ T-cells in both pancreatic and hepatocellular cancer, whereas ICAM-1 and Mac-1 are dispensable.
DOI:doi:10.1002/ijc.26223
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext ; Verlag: http://dx.doi.org/10.1002/ijc.26223
 kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.26223
 DOI: https://doi.org/10.1002/ijc.26223
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:hepatocellular cancer
 leukocyte recruitment
 pancreatic cancer
 time-lapse intravital microscopy
 β2-integrins
K10plus-PPN:1577312171
Verknüpfungen:→ Zeitschrift

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