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Verfasst von:Jakob, Jens [VerfasserIn]   i
 Ronellenfitsch, Ulrich [VerfasserIn]   i
 Hohenberger, Peter [VerfasserIn]   i
Titel:Gastrointestinal stromal tumor of the rectum
Titelzusatz:results of surgical and multimodality therapy in the era of imatinib
Verf.angabe:Jens Jakob, Chiara Mussi, Ulrich Ronellenfitsch, Eva Wardelmann, Tiziana Negri, Alessandro Gronchi, Peter Hohenberger
Jahr:2013
Jahr des Originals:2012
Umfang:7 S.
Fussnoten:Published online: 11 September 2012 ; Gesehen am 05.07.2018
Titel Quelle:Enthalten in: Annals of surgical oncology
Ort Quelle:Berlin [u.a.] : Springer, 1994
Jahr Quelle:2013
Band/Heft Quelle:20(2013), 2, Seite 586-592
ISSN Quelle:1534-4681
Abstract:Background: The rectum is a rare site of gastrointestinal stromal tumor (GIST), and factors determining long-term outcome remain unclear. In a population study, we assessed the outcome of rectal GIST patients treated at two referral centers.MethodsA total of 39 patients diagnosed with rectal GIST between January 2002 and December 2010 were identified in prospective databases. Tumor and patient characteristics, treatment details, and outcome were evaluated. Median follow-up was 41 (3-110) months.ResultsA male predominance was noticed (M/F = 29/10). Median age was 53 years (range, 32-80 years). The cohort included, of 39 patients, 12 low-risk, 26 high-risk, and 1 with M1 disease. Of 38 patients with nonmetastatic disease, 36 underwent surgery as transabdominal (15 of 36) or local (21 of 36) resection. There were 21 patients who received preoperative and/or postoperative imatinib treatment. Patients with preoperative imatinib (16 of 36) had a significantly higher rate of R0 resections (p = .02). Five patients developed local recurrences. All of them had undergone local tumor excision with positive margins and without perioperative imatinib. Also, five patients suffered from distant metastases. All belonged to the high-risk group and underwent tumor surgery (3 R0, 2 R1) without receiving perioperative imatinib. A total of three patients died of disease. Perioperative imatinib was associated with improved local disease-free, disease-free, and overall survival (p < .01, p < .01, and p = .03, respectively). Local disease-free survival was significantly improved by negative resection margins (p < .01).ConclusionsComplete resection is recommended to achieve local disease control. Preoperative imatinib was associated with improved surgical margins. Perioperative imatinib was associated with improved local disease-free, disease-free, and overall survival.
DOI:doi:10.1245/s10434-012-2647-1
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://link.springer.com/article/10.1245/s10434-012-2647-1
 Volltext: http://dx.doi.org/10.1245/s10434-012-2647-1
 DOI: https://doi.org/10.1245/s10434-012-2647-1
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1577323459
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