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Verfasst von:Bürger, Thomas [VerfasserIn]   i
 Marx, Alexander [VerfasserIn]   i
Titel:Metastatic type A thymoma
Titelzusatz:morphological and genetic correlation
Verf.angabe:Tobias Bürger, Inga-Marie Schaefer, Stefan Küffer, Hanibal Bohnenberger, Kirsten Reuter‐Jessen, John Kwok-Cheung Chan, Alexander Emmert, Marc Hinterthaner, Alexander Marx & Philipp Ströbel
Jahr:2017
Jahr des Originals:2016
Umfang:7 S.
Fussnoten:Published online, article accepted 7 December 2016 ; Gesehen am 06.07.2018
Titel Quelle:Enthalten in: Histopathology
Ort Quelle:Oxford [u.a.] : Wiley-Blackwell, 1977
Jahr Quelle:2017
Band/Heft Quelle:70(2017), 5, Seite 704-710
ISSN Quelle:1365-2559
Abstract:Aims The vast majority of type A thymomas are diagnosed in tumour stages 1 or 2, and metastatic cases are exceedingly rare. The histological and genetic features of such metastatic type A thymomas have not been described in detail. Methods and results Five metastatic type A thymomas in tumour stage Masaoka IVb that had been reviewed by a panel of expert pathologists were analysed using comparative genomic hybridization (CGH). Cases 1, 2 and 3 showed the prototypical morphology of type A thymomas with mainly solid growth patterns. These cases displayed only very subtle nuclear irregularities and slight nuclear crowding, but no other atypical features. Mitoses were absent. Cases 3 and 4, in contrast, had a distinctly atypical morphology. CGH revealed partially recurrent alterations in four cases (with and without atypical morphology), including gains on chromosome 1q (one case), 17q (two cases), chromosome 19 (three cases) and 22q (one case) and losses on chromosome 17p (two cases) and 22q (one case). Conclusion Rare metastatic type A thymomas, both with typical and ‘atypical’ histological features, show partially recurrent genomic alterations that differ from the much more frequent localized and indolent tumours. The fact that these alterations were recurring points to a link between clinical behaviour and molecular features. Our findings may have implications for the management and treatment of such tumours.
DOI:doi:10.1111/his.13138
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1111/his.13138
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/his.13138
 DOI: https://doi.org/10.1111/his.13138
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:atypical
 comparative genomic hybridization
 type A thymoma
K10plus-PPN:1577383729
Verknüpfungen:→ Zeitschrift

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