| |  Online-Ressource |
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| Verfasst von: | Winkler, Julia K. [VerfasserIn]  |
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| | Bender, Carolin [VerfasserIn] |
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| | Lang, Nina [VerfasserIn] |
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| | Zeier, Martin [VerfasserIn] |
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| | Enk, Alexander [VerfasserIn] |
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| | Hassel, Jessica C. [VerfasserIn] |
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| Titel: | Safe administration of an anti-PD-1 antibody to kidney-transplant patients |
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| Titelzusatz: | 2 clinical cases and review of the literature |
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| Verf.angabe: | Julia K. Winkler, Ralf Gutzmer, Carolin Bender, Nina Lang, Martin Zeier, Alexander H. Enk, and Jessica C. Hassel |
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| E-Jahr: | 2017 |
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| Jahr: | November 1, 2017 |
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| Umfang: | 4 S. |
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| Fussnoten: | Gesehen am 09.07.2018 |
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| Titel Quelle: | Enthalten in: Journal of immunotherapy |
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| Ort Quelle: | Philadelphia, Pa. : Lippincott Williams & Wilkins, 1991 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 40(2017), 9, Seite 341-344 |
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| ISSN Quelle: | 1537-4513 |
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| Abstract: | Antiprogrammed cell-death protein 1 (PD-1) antibodies have revolutionized therapy of metastatic melanoma and other tumors, but some subgroups of patients such as immunosuppressed patients after solid-organ transplantation, have regularly been excluded from clinical studies. We report 2 cases of kidney-transplant patients who received an anti-PD-1 antibody to treat metastatic melanoma. Treatment was tolerated well with no relevant adverse events and stable kidney functions, but the melanoma progressed in both patients. Factors potentially affecting risk of allograft rejection and response to treatment, for example, immunosuppressive regimen and therapeutic sequence, are discussed on the basis of current literature. Further studies are necessary to determine the risk of allograft rejection and the therapeutic benefit of anti-PD-1 antibodies for organ-transplanted patients, in particular as these checkpoint inhibitors have become therapeutic standard in a variety of tumors other than melanoma. |
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| DOI: | doi:10.1097/CJI.0000000000000188 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag ; Resolving-System: https://journals.lww.com/immunotherapy-journal/Fulltext/2017/11000/Safe_Administration_of_An_Anti_PD_1_Antibody_to.4.asp ... |
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| | Volltext: http://dx.doi.org/10.1097/CJI.0000000000000188 |
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| | DOI: https://doi.org/10.1097/CJI.0000000000000188 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1577422066 |
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| Verknüpfungen: | → Zeitschrift |
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Safe administration of an anti-PD-1 antibody to kidney-transplant patients / Winkler, Julia K. [VerfasserIn]; November 1, 2017 (Online-Ressource)
