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| Verfasst von: | Santos, David M. Cordas dos [VerfasserIn]  |
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| | Eilers, Juliane [VerfasserIn] |
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| | Orlova, Elena [VerfasserIn] |
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| | Börner, Kathleen [VerfasserIn] |
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| | Grimm, Dirk [VerfasserIn] |
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| | Muckenthaler, Martina [VerfasserIn] |
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| | Kulozik, Andreas [VerfasserIn] |
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| | Kunz, Joachim [VerfasserIn] |
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| Titel: | MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-[kappa]B |
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| Verf.angabe: | David M. Cordas dos Santos, Juliane Eilers, Alfonso Sosa Vizcaino, Elena Orlova, Martin Zimmermann, Martin Stanulla, Martin Schrappe, Kathleen Börner, Dirk Grimm, Martina U. Muckenthaler, Andreas E. Kulozik and Joachim B. Kunz |
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| E-Jahr: | 2018 |
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| Jahr: | 18 June 2018 |
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| Fussnoten: | Gesehen am 10.07.2018 |
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| Titel Quelle: | Enthalten in: BMC cancer |
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| Ort Quelle: | London : BioMed Central, 2001 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 18(2018) Artikel-Nummer 663, 12 Seiten |
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| ISSN Quelle: | 1471-2407 |
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| Abstract: | Deletions of 6q15-16.1 are recurrently found in pediatric T-cell acute lymphoblastic leukemia (T-ALL). This chromosomal region includes the mitogen-activated protein kinase kinase kinase 7 (MAP3K7) gene which has a crucial role in innate immune signaling and was observed to be functionally and prognostically relevant in different cancer entities. Therefore, we correlated the presence of MAP3K7 deletions with clinical parameters in a cohort of 327 pediatric T-ALL patients and investigated the function of MAP3K7 in the T-ALL cell lines CCRF-CEM, Jurkat and MOLT-4. |
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| DOI: | doi:10.1186/s12885-018-4525-0 |
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| URL: | Kostenfrei: Volltext ; Verlag: http://dx.doi.org/10.1186/s12885-018-4525-0 |
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| | Kostenfrei: Volltext: https://doi.org/10.1186/s12885-018-4525-0 |
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| | DOI: https://doi.org/10.1186/s12885-018-4525-0 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | chr6q15 deletion |
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| | MAP3K7 |
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| | T-ALL |
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| | T-cell acute lymphoblastic leukemia |
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| | TGF-beta activated kinase 1 |
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| K10plus-PPN: | 1577451821 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-[kappa]B / Santos, David M. Cordas dos [VerfasserIn]; 18 June 2018 (Online-Ressource)
