| |  Online-Ressource |
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| Verfasst von: | Arcourt, Alice [VerfasserIn]  |
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| | Gorham, Louise [VerfasserIn] |
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| | Prato, Vincenzo [VerfasserIn] |
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| | Taberner, Francisco J. [VerfasserIn] |
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| | Wende, Hagen [VerfasserIn] |
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| | Gangadharan, Vijayan [VerfasserIn] |
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| | Lechner, Stefan [VerfasserIn] |
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| Titel: | Touch receptor-derived sensory information alleviates acute pain signaling and fine-tunes nociceptive reflex coordination |
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| Verf.angabe: | Alice Arcourt, Louise Gorham, Rahul Dhandapani, Vincenzo Prato, Francisco J. Taberner, Hagen Wende, Vijayan Gangadharan, Carmen Birchmeier, Paul A. Heppenstall, Stefan G. Lechner |
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| Jahr: | 2017 |
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| Jahr des Originals: | 2016 |
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| Umfang: | 15 S. |
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| Fussnoten: | Published: December 15, 2016 ; Gesehen am 10.07.2018 |
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| Titel Quelle: | Enthalten in: Neuron |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1988 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 93(2017), 1, Seite 179-193 |
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| ISSN Quelle: | 1097-4199 |
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| Abstract: | Painful mechanical stimuli activate multiple peripheral sensory afferent subtypes simultaneously, including nociceptors and low-threshold mechanoreceptors (LTMRs). Using an optogenetic approach, we demonstrate that LTMRs do not solely serve as touch receptors but also play an important role in acute pain signaling. We show that selective activation of neuropeptide Y receptor-2-expressing (Npy2r) myelinated A-fiber nociceptors evokes abnormally exacerbated pain, which is alleviated by concurrent activation of LTMRs in a frequency-dependent manner. We further show that spatial summation of single action potentials from multiple NPY2R-positive afferents is sufficient to trigger nocifensive paw withdrawal, but additional simultaneous sensory input from LTMRs is required for normal well-coordinated execution of this reflex. Thus, our results show that combinatorial coding of noxious and tactile sensory input is required for normal acute mechanical pain signaling. Additionally, we established a causal link between precisely defined neural activity in functionally identified sensory neuron subpopulations and nocifensive behavior and pain. |
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| DOI: | doi:10.1016/j.neuron.2016.11.027 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: http://dx.doi.org/10.1016/j.neuron.2016.11.027 |
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| | DOI: https://doi.org/10.1016/j.neuron.2016.11.027 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | A-fiber mechanonociceptors |
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| | Action Potentials |
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| | Acute Pain |
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| | Animals |
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| | dorsal root ganglion |
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| | Ganglia, Spinal |
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| | Immunohistochemistry |
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| | MafA |
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| | Mechanoreceptors |
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| | Mice |
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| | Nerve Fibers, Myelinated |
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| | Neurons |
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| | Nociceptors |
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| | Npy2r |
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| | Optogenetics |
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| | Patch-Clamp Techniques |
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| | pinprick pain |
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| | Postsynaptic Potential Summation |
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| | primary afferent |
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| | Real-Time Polymerase Chain Reaction |
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| | Receptors, Neuropeptide Y |
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| | Reflex |
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| | Reverse Transcriptase Polymerase Chain Reaction |
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| K10plus-PPN: | 1577445007 |
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| Verknüpfungen: | → Zeitschrift |
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Touch receptor-derived sensory information alleviates acute pain signaling and fine-tunes nociceptive reflex coordination / Arcourt, Alice [VerfasserIn]; 2017 (Online-Ressource)
