| Online-Ressource |
Verfasst von: | Breyer, Johannes [VerfasserIn]  |
| Erben, Philipp [VerfasserIn]  |
| Worst, Thomas [VerfasserIn]  |
Titel: | High PDL1 mRNA expression predicts better survival of stage pT1 non-muscle-invasive bladder cancer (NMIBC) patients |
Verf.angabe: | Johannes Breyer, Ralph M. Wirtz, Wolfgang Otto, Philipp Erben, Thomas S. Worst, Robert Stoehr, Markus Eckstein, Stefan Denzinger, Maximilian Burger, Arndt Hartmann |
Jahr: | 2018 |
Jahr des Originals: | 2017 |
Umfang: | 10 S. |
Fussnoten: | Published online: 17 November 2017 ; Gesehen am 10.07.2018 |
Titel Quelle: | Enthalten in: Cancer immunology immunotherapy |
Ort Quelle: | Berlin : Springer, 1976 |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 67(2018), 3, Seite 403-412 |
ISSN Quelle: | 1432-0851 |
Abstract: | Introduction and objectivesCheckpoint inhibition has emerged as new therapeutic option in muscle-invasive bladder cancer. The objective of the present study was to evaluate the prognostic role of PD1 and PDL1 expression in non-muscle-invasive bladder cancer (NMIBC) and establish an objective measuring method using RNA quantification.Materials and methodsWe retrospectively analyzed clinical data and formalin-fixed paraffin-embedded tissues (FFPE) of patients with stage pT1 NMIBC who underwent transurethral resection of the bladder. mRNA expression of PD1, PDL1 and CD3 was measured by single step RT-qPCR and correlated to clinicopathological parameters, recurrence-free survival (RFS), progression-free survival (PFS) and carcinoma-specific survival (CSS).ResultsWe have analyzed 334 patients with NMIBC at stage pT1 for mRNA analysis. Data from 296 patients (79% male, median age: 72 years) could be used. Spearman correlation revealed significant associations between mRNA expressions of PD1/PDL1 (ρ: 0.6024, p < 0.0001), CD3/PDL1 (ρ: 0.5728, p < 0.0001) and CD3/PD1 (ρ: 0.7005, p < 0.0001). Kaplan-Meier analysis revealed that high PDL1 mRNA expression (≥ 33.83) is a favorable prognostic factor with regard to better RFS (p = 0.0018), PFS (p = 0.021) and CSS (p = 0.012). Multivariate Cox-regression analysis proved PDL1 expression to be an independent prognosticator for RFS [HR 0.48 (0.31-0.72), p = 0.0005], PFS [HR 0.45 (0.24-0.80), p = 0.0059] and CSS [HR 0.31 (0.13-0.67), p = 0.0021].ConclusionHigh mRNA expression of PDL1 predicts improved RFS, PFS and CSS of pT1 NMIBC. Following prospective validation, this objective measurement of PD-L1 might help stratify patients with NMIBC for immunotherapy and identify patients who might benefit from early cystectomy. |
DOI: | doi:10.1007/s00262-017-2093-9 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1007/s00262-017-2093-9 |
| Volltext: https://link.springer.com/article/10.1007/s00262-017-2093-9 |
| DOI: https://doi.org/10.1007/s00262-017-2093-9 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1577451198 |
Verknüpfungen: | → Zeitschrift |
High PDL1 mRNA expression predicts better survival of stage pT1 non-muscle-invasive bladder cancer (NMIBC) patients / Breyer, Johannes [VerfasserIn]; 2018 (Online-Ressource)