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Verfasst von:Toltz, Allison [VerfasserIn]   i
 Hösl, Michaela [VerfasserIn]   i
Titel:Time-resolved diode dosimetry calibration through Monte Carlo modeling for in vivo passive scattered proton therapy range verification
Verf.angabe:Allison Toltz, Michaela Hoesl, Jan Schuemann, Jan Seuntjens, Hsiao-Ming Lu, Harald Paganetti
Umfang:6 S.
Fussnoten:Gesehen am 11.07.2018
Titel Quelle:Enthalten in: Journal of applied clinical medical physics
Jahr Quelle:2017
Band/Heft Quelle:18(2017), 6, S. 200-205
ISSN Quelle:1526-9914
Abstract:Purpose: Our group previously introduced an in vivo proton range verification methodology in which a silicon diode array system is used to correlate the dose rate profile per range modulation wheel cycle of the detector signal to the water-equivalent path length (WEPL) for passively scattered proton beam delivery. The implementation of this system requires a set of calibration data to establish a beam-specific response to WEPL fit for the selected ‘scout’ beam (a 1 cm overshoot of the predicted detector depth with a dose of 4 cGy) in water-equivalent plastic. This necessitates a separate set of measurements for every ‘scout’ beam that may be appropriate to the clinical case. The current study demonstrates the use of Monte Carlo simulations for calibration of the time-resolved diode dosimetry technique. Methods: Measurements for three ‘scout’ beams were compared against simulated detector response with Monte Carlo methods using the Tool for Particle Simulation (TOPAS). The ‘scout’ beams were then applied in the simulation environment to simulated water-equivalent plastic, a CT of water-equivalent plastic, and a patient CT data set to assess uncertainty. Results: Simulated detector response in water-equivalent plastic was validated against measurements for ‘scout’ spread out Bragg peaks of range 10 cm, 15 cm, and 21 cm (168 MeV, 177 MeV, and 210 MeV) to within 3.4 mm for all beams, and to within 1 mm in the region where the detector is expected to lie. Conclusion: Feasibility has been shown for performing the calibration of the detector response for three ‘scout’ beams through simulation for the time-resolved diode dosimetry technique in passive scattered proton delivery.
DOI:doi:10.1002/acm2.12210
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Kostenfrei: Verlag: http://dx.doi.org/10.1002/acm2.12210
 Kostenfrei: Verlag: https://aapm.onlinelibrary.wiley.com/doi/abs/10.1002/acm2.12210
 DOI: https://doi.org/10.1002/acm2.12210
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1577520033
Verknüpfungen:→ Zeitschrift

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