Circulating dopamine and c-peptide levels in fasting nondiabetic hypertensive patients

• Verfasst von: Tomaschitz, Andreas [VerfasserIn]
• Verfasst von: Ritz, Eberhard [VerfasserIn]
• Verfasst von: März, Winfried [VerfasserIn]
• Verfasst von: Pilz, Stefan [VerfasserIn]
• Titel: Circulating dopamine and c-peptide levels in fasting nondiabetic hypertensive patients
• Titelzusatz: the Graz endocrine causes of hypertension study
• Verf.angabe: Andreas Tomaschitz, Eberhard Ritz, Katharina Kienreich, Burkert Pieske, Winfried März, Bernhard O. Boehm, Christiane Drechsler, Andreas Meinitzer, Stefan Pilz
• Jahr: 2012
• Umfang: 3 S.
• Fussnoten: Gesehen am 11.07.2018
• Titel Quelle: Enthalten in: Diabetes care
• Ort Quelle: Alexandria, Va. : Assoc., 1978
• Jahr Quelle: 2012
• Band/Heft Quelle: 35(2012), 8, Seite 1771-1773
• ISSN Quelle: 1935-5548
• DOI: doi:10.2337/dc11-2384
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1577523431

Abstract

OBJECTIVE: Accumulating evidence supports a potential role for dopamine in the regulation of insulin secretion. We examined the association between circulating dopamine and C-peptide concentrations using data from the Graz Endocrine Causes of Hypertension (GECOH) study. RESEARCH DESIGN AND METHODS: After 12 h of fasting, we measured plasma dopamine and serum C-peptide levels and established determining factors of insulin secretion in 201 nondiabetic hypertensive patients (mean age 48.1 ± 16.0 years; 61.7% women). RESULTS: Mean dopamine and C-peptide concentration were 33.4 ± 38.6 pg/mL and 3.1 ± 2.7 ng/mL, respectively. A strong and inverse correlation was observed between dopamine and C-peptide levels (r = −0.423, P < 0.001). There was no significant relationship between C-peptide, plasma epinephrine, and norepinephrine. C-peptide levels decreased steadily and significantly from tertile 1 of dopamine (3.6 ng/mL [95% CI 2.9-4.1]) to tertile 3 (1.6 ng/mL [1.5-2.7], P < 0.001) after multivariate adjustment. CONCLUSIONS: The inverse association between dopamine and C-peptide highlights the need to evaluate whether dopamine could be effective for modulating endocrine pancreatic function.