| Online-Ressource |
Verfasst von: | Tomaschitz, Andreas [VerfasserIn]  |
| Ritz, Eberhard [VerfasserIn]  |
| März, Winfried [VerfasserIn]  |
| Pilz, Stefan [VerfasserIn]  |
Titel: | Circulating dopamine and c-peptide levels in fasting nondiabetic hypertensive patients |
Titelzusatz: | the Graz endocrine causes of hypertension study |
Verf.angabe: | Andreas Tomaschitz, Eberhard Ritz, Katharina Kienreich, Burkert Pieske, Winfried März, Bernhard O. Boehm, Christiane Drechsler, Andreas Meinitzer, Stefan Pilz |
Jahr: | 2012 |
Umfang: | 3 S. |
Fussnoten: | Gesehen am 11.07.2018 |
Titel Quelle: | Enthalten in: Diabetes care |
Ort Quelle: | Alexandria, Va. : Assoc., 1978 |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 35(2012), 8, Seite 1771-1773 |
ISSN Quelle: | 1935-5548 |
Abstract: | OBJECTIVE: Accumulating evidence supports a potential role for dopamine in the regulation of insulin secretion. We examined the association between circulating dopamine and C-peptide concentrations using data from the Graz Endocrine Causes of Hypertension (GECOH) study. RESEARCH DESIGN AND METHODS: After 12 h of fasting, we measured plasma dopamine and serum C-peptide levels and established determining factors of insulin secretion in 201 nondiabetic hypertensive patients (mean age 48.1 ± 16.0 years; 61.7% women). RESULTS: Mean dopamine and C-peptide concentration were 33.4 ± 38.6 pg/mL and 3.1 ± 2.7 ng/mL, respectively. A strong and inverse correlation was observed between dopamine and C-peptide levels (r = −0.423, P < 0.001). There was no significant relationship between C-peptide, plasma epinephrine, and norepinephrine. C-peptide levels decreased steadily and significantly from tertile 1 of dopamine (3.6 ng/mL [95% CI 2.9-4.1]) to tertile 3 (1.6 ng/mL [1.5-2.7], P < 0.001) after multivariate adjustment. CONCLUSIONS: The inverse association between dopamine and C-peptide highlights the need to evaluate whether dopamine could be effective for modulating endocrine pancreatic function. |
DOI: | doi:10.2337/dc11-2384 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: http://dx.doi.org/10.2337/dc11-2384 |
| kostenfrei: Volltext: http://care.diabetesjournals.org/content/35/8/1771 |
| DOI: https://doi.org/10.2337/dc11-2384 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1577523431 |
Verknüpfungen: | → Zeitschrift |
Circulating dopamine and c-peptide levels in fasting nondiabetic hypertensive patients / Tomaschitz, Andreas [VerfasserIn]; 2012 (Online-Ressource)