| |  Online-Ressource |
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| Verfasst von: | Dollt, Claudia [VerfasserIn]  |
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| | Becker, Kathrin [VerfasserIn] |
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| | Michel, Julia [VerfasserIn] |
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| | Melchers, Susanne [VerfasserIn] |
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| | Weis, Cleo-Aron Thias [VerfasserIn] |
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| | Schledzewski, Kai [VerfasserIn] |
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| | Krewer, Andreas [VerfasserIn] |
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| | Kloss, Loreen [VerfasserIn] |
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| | Gebhardt, Christoffer [VerfasserIn] |
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| | Utikal, Jochen [VerfasserIn] |
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| | Schmieder, Astrid [VerfasserIn] |
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| Titel: | The shedded ectodomain of Lyve-1 expressed on M2-like tumor-associated macrophages inhibits melanoma cell proliferation |
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| Verf.angabe: | Claudia Dollt, Kathrin Becker, Julia Michel, Susanne Melchers, Cleo-Aron Weis, Kai Schledzewski, Andreas Krewer, Loreen Kloss, Christoffer Gebhardt, Jochen Utikal and Astrid Schmieder |
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| E-Jahr: | 2017 |
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| Jahr: | October 10, 2017 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 12.07.2018 |
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| Titel Quelle: | Enthalten in: OncoTarget |
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| Ort Quelle: | [Erscheinungsort nicht ermittelbar] : Impact Journals LLC, 2010 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 8(2017), 61, Seite 103682-103692 |
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| ISSN Quelle: | 1949-2553 |
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| Abstract: | Targeting immune cells that support tumor growth is an effective therapeutic strategy in tumor entities such as melanoma. M2-like tumor-associated macrophages (TAM) sustain tumor growth by secreting anti-inflammatory cytokines, proteases and growth factors. In this study, we show that a protein derived from M2-like macrophages namely the shedded ectodomain of Lyve-1 (sLyve-1) decreases human HT144 and murine B16F1 melanoma cell proliferation significantly by acting as a decoy receptor for lowmolecular weight hyaluronic acid (LMW-HA) although the LMW-HA/Lyve-1 interaction on lymphatic endothelial cells has been described to induce lymphangiogenesis. This is in line with our finding that the number of LYVE-1+ TAM decreases in higher human melanoma stages and that the early growth of B16 transplant tumors is enhanced in Lyve-1 knockout mice when compared to wild-type mice due to an increased melanoma cell proliferation. LYVE-1 expressing TAM are however true M2 macrophages as they coexpress typical M2-markers such as CD163 and CD206. The results of the present study highlight the necessity to carefully determine the net effect particular TAM subpopulations have on tumors before establishing a treatment to target these immune cells. |
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| DOI: | doi:10.18632/oncotarget.21771 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.18632/oncotarget.21771 |
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| | Volltext: http://www.oncotarget.com/fulltext/21771 |
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| | DOI: https://doi.org/10.18632/oncotarget.21771 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1577533054 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ shedded ectodomain of Lyve-1 expressed on M2-like tumor-associated macrophages inhibits melanoma cell proliferation / Dollt, Claudia [VerfasserIn]; October 10, 2017 (Online-Ressource)
