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Verfasst von:Kasten, Philip [VerfasserIn]   i
 Beverungen, Mirjam [VerfasserIn]   i
 Lorenz, Helga [VerfasserIn]   i
 Geiger, Florian [VerfasserIn]   i
Titel:Comparison of platelet-rich plasma and VEGF-transfected mesenchymal stem cells on vascularization and bone formation in a critical-size bone defect
Verf.angabe:P. Kasten, M. Beverungen, H. Lorenz, J. Wieland, M. Fehr, F. Geiger
Umfang:11 S.
Fussnoten:Gesehen am 12.07.2018
Titel Quelle:Enthalten in: Cells tissues organs
Jahr Quelle:2012
Band/Heft Quelle:196(2012), 6, S. 523-533
ISSN Quelle:1422-6421
Abstract:Both platelet-rich plasma (PRP) and vascular endothelial growth factor (VEGF) can promote regeneration. The aim of this study was to compare the effects of these two elements on bone formation and vascularization in combination with bone marrow stromal cells (BMSC) in a critical-size bone defect in rabbits. The critical-size defects of the radius were filled with: (1) a calcium-deficient hydroxyapatite (CDHA) scaffold + phVEGF<sub>165</sub>-transfected BMSC (VEGF group), (2) CDHA and PRP, or (3) CDHA, autogenous BMSC, and PRP. As controls served: (4) the CDHA scaffold alone and (5) the CDHA scaffold and autogenous BMSC. The volume of new bone was measured by means of micro-CT scans, and vascularization was assessed in histology after 16 weeks. Bone formation was higher in the PRP + CDHA, BMSC + CDHA, and PRP + BMSC + CDHA groups than in the VEGF group (p < 0.05). VEGF transfection significantly promoted vascularization of the scaffolds in contrast to BMSC and PRP (p < 0.05), but was similar to the result of the CDHA + PRP + BMSC group. The results show that VEGF-transfected BMSC as well as the combination of PRP and BMSC improve vascularization, but bone healing was better with the combination of BMSC and PRP than with VEGF-transfected BMSC. Expression of VEGF in BMSC as a single growth factor does not seem to be as effective for bone formation as expanded BMSC alone or PRP which contains a mixture of growth factors.
DOI:doi:10.1159/000337490
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Verlag: http://dx.doi.org/10.1159/000337490
 Verlag: https://www.karger.com/Article/FullText/337490
 DOI: https://doi.org/10.1159/000337490
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1577536150
Verknüpfungen:→ Zeitschrift

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