Elevated preoperative CEA is associated with worse survival in stage I-III rectal cancer patients

• Verfasst von: Tarantino, Ignazio [VerfasserIn]
• Verfasst von: Warschkow, René [VerfasserIn]
• Titel: Elevated preoperative CEA is associated with worse survival in stage I-III rectal cancer patients
• Verf.angabe: I. Tarantino, R. Warschkow, M. Worni, K. Merati-Kashani, D. Köberle, B.M. Schmied, S.A. Müller, T. Steffen, T. Cerny and U. Güller
• E-Jahr: 2012
• Jahr: 26 June 2012
• Umfang: 9 S.
• Fussnoten: Gesehen am 12.07.2018 ; Corrected online 03 July 2012, published online 26 June 2012
• Titel Quelle: Enthalten in: British journal of cancer
• Ort Quelle: Edinburgh : Nature Publ. Group, 1999
• Jahr Quelle: 2012
• Band/Heft Quelle: 107(2012), 2, Seite 266-274
• ISSN Quelle: 1532-1827
• DOI: doi:10.1038/bjc.2012.267
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1577544870

Abstract

Background:The objective of this investigation was to assess whether preoperative carcinoembryonic antigen (CEA) level is an independent predictor of overall survival in rectal cancer patients.Methods:All patients (n=504) undergoing a resection for stage I-III rectal cancer at the Kantonsspital St Gallen were included into a database between 1991 and 2008. The impact of preoperative CEA level on overall survival was assessed using risk-adjusted Cox proportional hazard regression models and propensity score methods.Results:In risk-adjusted Cox proportional hazard regression analyses, preoperative CEA level (hazard ratio (HR): 1.98, 95% confidence interval (CI): 1.36-2.90, P<0.001), distance from anal verge (<5 cm: HR: 1.93, 95% CI: 1.11-3.37; P=0.039), older age (HR: 1.07, 95% CI: 1.05-1.09; P<0.001), lower body mass index (HR: 0.94, 95% CI: 0.89-0.98; P=0.006), advanced tumour stage (stage II HR: 1.41, 95% CI: 0.85-2.32; stage III HR: 2.08, 95% CI: 1.31-3.31; P=0.004), R 1 resection (HR: 5.65, 95% CI: 1.59-20.1; P=0.005) and chronic kidney disease (HR: 2.28, 95% CI: 1.03-5.04; P=0.049) were all predictors for poor overall survival.Conclusion:This is one of the first investigations based on a large cohort of exclusively rectal cancer patients demonstrating that preoperative CEA level is a strong predictor of decreased overall survival. Preoperative CEA should be used as a prognostic factor in the preoperative assessment of rectal cancer patients.