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Status: Bibliographieeintrag

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Verfasst von:Hirth, Michael [VerfasserIn]   i
 Vujasinovic, Miroslav [VerfasserIn]   i
 Münch, Markus [VerfasserIn]   i
 Weiß, Christel [VerfasserIn]   i
 Ebert, Matthias [VerfasserIn]   i
 Schneider, Alexander [VerfasserIn]   i
Titel:Monitoring and predicting disease activity in autoimmune pancreatitis with the M-ANNHEIM-AiP-Activity-Score
Verf.angabe:Michael Hirth, Miroslav Vujasinovic, Markus Münch, Christel Weiss, Matthias Löhr, Matthias P. Ebert, Alexander Schneider
Jahr:2018
Jahr des Originals:2017
Umfang:10 S.
Fussnoten:Available online 25 October 2017 ; Gesehen am 12.07.2018
Titel Quelle:Enthalten in: Pancreatology
Ort Quelle:Amsterdam : Elsevier, 2001
Jahr Quelle:2018
Band/Heft Quelle:18(2018), 1, Seite 29-38
ISSN Quelle:1424-3911
Abstract:Background & objectives: Autoimmune pancreatitis (AiP) is treated by immunosuppressive therapy. Exact description of disease activity of AiP is essential in clinical practice and research, but a score to describe the disease activity is missing. Thus, we aimed to establish an activity score of AiP. Methods: We retrospectively studied long-term disease courses of 29 patients with AiP (Mannheim, Germany), receiving corticosteroid treatment (CST) by analyzing 613 treatment appointments. Two assumptions were made: First, disease activity is higher at emergency treatments; second, disease activity drops under CST. In all patients, we evaluated established activity- and classification-systems of chronic pancreatitis (cP). Based on the most suitable system, we established an activity score of AiP by including AiP-specific parameters identified from our long-term disease courses and the literature. The new AiP-specific activity score was validated in an external cohort of 14 patients with AiP (Stockholm, Sweden). Results: Within published activity indexes of cP, the M-ANNHEIM-classification most significantly correlated with emergency- and treatment-dependent disease activities (p < 0.001 and p < 0.01, conditional-logistic-regression-analysis). Significant correlations of disease activity were found for several clinical parameters (biliary involvement, extrapancreatic lesions, acute pancreatitis, focal pancreatic mass, pancreatic sausage/mass, focal enlargement, ascites; p < 0.05, Wilcoxon-signed-rank-test). Based on these data and disease features from the literature, the M-ANNHEIM-AiP-Activity-Score (MAAS) was established. CST-induced reduction of MAAS disease activity of more than 60% was associated with lower relapse rates (p < 0.05; Chi-Square-test). The results were validated in the external patient cohort. Conclusion: The MAAS might represent a useful tool to monitor AiP.
DOI:doi:10.1016/j.pan.2017.10.005
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.pan.2017.10.005
 Volltext: http://www.sciencedirect.com/science/article/pii/S142439031730858X
 DOI: https://doi.org/10.1016/j.pan.2017.10.005
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Autoimmune pancreatitis
 Disease activity
 Disease monitoring
 Score
K10plus-PPN:1577548388
Verknüpfungen:→ Zeitschrift

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