| Online-Ressource |
Verfasst von: | Hirth, Michael [VerfasserIn]  |
| Vujasinovic, Miroslav [VerfasserIn]  |
| Münch, Markus [VerfasserIn]  |
| Weiß, Christel [VerfasserIn]  |
| Ebert, Matthias [VerfasserIn]  |
| Schneider, Alexander [VerfasserIn]  |
Titel: | Monitoring and predicting disease activity in autoimmune pancreatitis with the M-ANNHEIM-AiP-Activity-Score |
Verf.angabe: | Michael Hirth, Miroslav Vujasinovic, Markus Münch, Christel Weiss, Matthias Löhr, Matthias P. Ebert, Alexander Schneider |
Jahr: | 2018 |
Jahr des Originals: | 2017 |
Umfang: | 10 S. |
Fussnoten: | Available online 25 October 2017 ; Gesehen am 12.07.2018 |
Titel Quelle: | Enthalten in: Pancreatology |
Ort Quelle: | Amsterdam : Elsevier, 2001 |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 18(2018), 1, Seite 29-38 |
ISSN Quelle: | 1424-3911 |
Abstract: | Background & objectives: Autoimmune pancreatitis (AiP) is treated by immunosuppressive therapy. Exact description of disease activity of AiP is essential in clinical practice and research, but a score to describe the disease activity is missing. Thus, we aimed to establish an activity score of AiP. Methods: We retrospectively studied long-term disease courses of 29 patients with AiP (Mannheim, Germany), receiving corticosteroid treatment (CST) by analyzing 613 treatment appointments. Two assumptions were made: First, disease activity is higher at emergency treatments; second, disease activity drops under CST. In all patients, we evaluated established activity- and classification-systems of chronic pancreatitis (cP). Based on the most suitable system, we established an activity score of AiP by including AiP-specific parameters identified from our long-term disease courses and the literature. The new AiP-specific activity score was validated in an external cohort of 14 patients with AiP (Stockholm, Sweden). Results: Within published activity indexes of cP, the M-ANNHEIM-classification most significantly correlated with emergency- and treatment-dependent disease activities (p < 0.001 and p < 0.01, conditional-logistic-regression-analysis). Significant correlations of disease activity were found for several clinical parameters (biliary involvement, extrapancreatic lesions, acute pancreatitis, focal pancreatic mass, pancreatic sausage/mass, focal enlargement, ascites; p < 0.05, Wilcoxon-signed-rank-test). Based on these data and disease features from the literature, the M-ANNHEIM-AiP-Activity-Score (MAAS) was established. CST-induced reduction of MAAS disease activity of more than 60% was associated with lower relapse rates (p < 0.05; Chi-Square-test). The results were validated in the external patient cohort. Conclusion: The MAAS might represent a useful tool to monitor AiP. |
DOI: | doi:10.1016/j.pan.2017.10.005 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.pan.2017.10.005 |
| Volltext: http://www.sciencedirect.com/science/article/pii/S142439031730858X |
| DOI: https://doi.org/10.1016/j.pan.2017.10.005 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Autoimmune pancreatitis |
| Disease activity |
| Disease monitoring |
| Score |
K10plus-PPN: | 1577548388 |
Verknüpfungen: | → Zeitschrift |
Monitoring and predicting disease activity in autoimmune pancreatitis with the M-ANNHEIM-AiP-Activity-Score / Hirth, Michael [VerfasserIn]; 2018 (Online-Ressource)