Online-Ressource | |
Verfasst von: | Arenja, Nisha [VerfasserIn] |
Fritz, Thomas [VerfasserIn] | |
André, Florian [VerfasserIn] | |
Riffel, Johannes [VerfasserIn] | |
Siepen, Fabian aus dem [VerfasserIn] | |
Ochs, Marco [VerfasserIn] | |
Paffhausen, Judith [VerfasserIn] | |
Hegenbart, Ute [VerfasserIn] | |
Schönland, Stefan [VerfasserIn] | |
Müller-Hennessen, Matthias [VerfasserIn] | |
Giannitsis, Evangelos [VerfasserIn] | |
Kristen, Arnt [VerfasserIn] | |
Katus, Hugo [VerfasserIn] | |
Friedrich, Matthias [VerfasserIn] | |
Buß, Sebastian Johannes [VerfasserIn] | |
Titel: | Myocardial contraction fraction derived from cardiovascular magnetic resonance cine images-reference values and performance in patients with heart failure and left ventricular hypertrophy |
Verf.angabe: | Nisha Arenja, Thomas Fritz, Florian Andre, Johannes H. Riffel, Fabian Aus dem Siepen, Marco Ochs, Judith Paffhausen, Ute Hegenbart, Stefan Schönland, Matthias Müller-Hennessen, Evangelos Giannitsis, Arnt V. Kristen, Hugo A. Katus, Matthias G. Friedrich, Sebastian J. Buss |
E-Jahr: | 2017 |
Jahr: | 6 February 2017 |
Umfang: | 9 S. |
Fussnoten: | Online publish-ahead-of-print 6 February 2017 ; Gesehen am 12.07.2018 |
Titel Quelle: | Enthalten in: European heart journal - cardiovascular imaging |
Ort Quelle: | Oxford : Oxford University Press, 2012 |
Jahr Quelle: | 2017 |
Band/Heft Quelle: | 18(2017), 12, Seite 1414-1422 |
ISSN Quelle: | 2047-2412 |
Abstract: | Aims: Left ventricular hypertrophy (LVH) has strong prognostic implications and is associated with heart failure. Recently, myocardial contraction fraction (MCF) was identified as a useful marker for specifically identifying cardiac amyloidosis (CA). The purpose of this study was to evaluate the diagnostic accuracy of MCF for the discrimination of different forms of LVH. Methods and results: We analysed cardiovascular magnetic resonance (CMR) scans of patients with CA (n = 132), hypertrophic cardiomyopathy (HCM, n = 60), hypertensive heart disease (HHD, n = 38) and in 100 age- and gender-matched healthy controls. MCF was calculated by dividing left ventricular (LV) stroke volume by LV myocardial volume. The diagnostic accuracy of MCF was compared to that of LV ejection fraction (EF) and the mass index (MI). Compared with controls (136.3 ± 24.4%, P < 0.05), mean values for MCF were significantly reduced in LVH (HHD:92.6 ± 20%, HCM:80 ± 20.3%, transthyretin CA:74.9 ± 32.2% and light-chain (AL) CA:50.5 ± 21.4%). MCF performed better than LVEF (AUC = 0.96 vs. AUC = 0.6, P < 0.001) and was comparable to LVMI (AUC = 0.95, P = 0.4) in discriminating LVH from controls. There was a significant yet weak correlation between MCF and LVEF (r = 0.43, P < 0.0001). MCF outperformed LVEF and LVMI in discriminating between different etiologies of LVH and between AL and other forms of LVH (AUC = 0.84, P < 0.0001). Moreover, cut-off values for MCF <50% and LVEF <60% allowed to identify patients with high probability for CA. Conclusion: In patients with heart failure MCF discriminates CA from other forms of LVH. As it can easily be derived from standard, non-contrast cine images, it may be a very useful marker in the diagnostic workup of patients with LVH. |
DOI: | doi:10.1093/ehjci/jew324 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt. Volltext: http://dx.doi.org/10.1093/ehjci/jew324 |
DOI: https://doi.org/10.1093/ehjci/jew324 | |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | cardiac amyloidosis |
heart failure | |
left ventricular ejection fraction | |
left ventricular hypertrophy | |
myocardial contraction fraction | |
K10plus-PPN: | 1577551907 |
Verknüpfungen: | → Zeitschrift |